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tumor DNA sequencing using FOUNDATION MEDICINE platform - has anyone done this?

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Prostate Cancer
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Posted 7/18/2017 1:38 AM (GMT 0)
hi there,

we were just advised to do tumor DNA sequencing using the foundation medicine platform - has anyone else done this?

if so, how does it work? did you ask your team to order it for you? which test?

all in all - was the information useful in re: to your treatment?

thanks for any/all feedback.
Posted 7/18/2017 2:03 AM (GMT 0)
No, but if you do it, let us know whether you found it useful!

My DH has had tumor (from biopsy of lymph node in neck) genetic testing though. Dave's testing was done by Caris Molecular Intelligence. His MO ordered it (with no input from us, and are we ever grateful!). Very very useful (he is responding well so far to Keytruda, which he qualified for based on the results of that test).

But he is likely to be the exception rather than the rule. Actionable genetic variants are probably rare. Though I think we don't know for sure.

Just curious, was it your doctor who suggested it?
Posted 7/18/2017 2:22 AM (GMT 0)
no, it wasn't my doctor who suggested it. it was emmanuel antonarakis from johns hopkins who responded to one of my queries.

we're doing the decipher test & the color test, but i had never heard of the foundation medicine platform until now.

will let you know what i find out!
Posted 7/18/2017 3:40 AM (GMT 0)
This might be the place with more info.

/www.foundationmedicine.com/genomic-testing

Charles
Posted 7/18/2017 10:56 PM (GMT 0)
Just wondering:
If one has several tumors, they could be genetically different. For instance, my prostate had sites that were Gleason 9 and others that were 7. Subjecting them all to sequencing must cost a bundle, as of today.
Any thoughts?
Posted 8/17/2017 2:06 PM (GMT 0)
Sr Sailor

That's an area of research interest (there was a recent article in Science). So I don't think anybody knows.

My (extremely limited understanding based) guess is that that might explain some of the non-or less complete - responders for some of the newer treatments.
Posted 8/17/2017 2:54 PM (GMT 0)
My husband is going in on Monday for his biopsy to have this done.
He had surgery 16 years ago, been on Lupron since, has had most of the drugs in those 16 years, 5 years ago 6 treatments of Taxotere, a month on Zytiga that wreaked havoc on his liver, and about 4 1/2 years on Xtandi. A new spot was found in his pelvic area earlier this year so, 5 treatments of Jevtana and his PSA was higher before treatment #5 than when chemo began. He has now had a CT scan and ultrasound done and we visit the doctor today for his PSA test to be repeated and get his 4 week Lupron check, also the results of the ultrasound. His doctor said we are now needing information for treatment, so this was his call. We are hoping and praying for some answers! I think the dr said it takes about 2 weeks to get the results. Hoping they can get the tissue needed from the growth in the pelvic area. Will let you know in 2 weeks what happened! We are using Foundation1 for the testing.
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