PSA COROLATES WITH TUMOR VOLUME??

We've gone around on this here in the past. Different Gleason types produce different amounts of PSA. It may change over time, but this has been reported by Dr Strum, though at present I don't have the link to where it's presented. This has been reported in previous threads here, discussed specifically with forum member JNF.

Different Gleason scores make different PSA per unit volume (ng/ml/cc): 4 for G6, 3 for G7, 2 for G8, 1 for G9 and .5 for G10. "Normal" cells make 0.066/cc.

You can play with some math for various proportions of normal vs tumor, and type of tumor tissue, to get insights from these production numbers.

Remember, this is a general guideline guideline to estimate tumor volume. You have to first determine how much PSA the actual prostate gives off then determine how much the cancer gives off and divide that by the G factor to determine the tumor volume. This approach doesn't seem important for you since you have a surgical pathology that tells you exactly what was going on with the prostate. With negative margins and nodes you assume all the cancer was contained so estimating volume doesn't seem relevent.

When my urologist and I made the estimates at dx we estimated my tumor volume to be about 19cc. Of course it doesn't tell you where the PCa is. I didn't have surgery thus no pathology. At the time we couldn't know whether the PCa was contained to the radiation field. Now seven years later with an undetectable PSA, our assumption is that the extended radiation field alleviated the cancer.