Warburg effect

It is known that a diet rich in fat can increase the risk of developing prostate cancer, and that obese people are more prone to develop this type of tumour. However, the fact that the metabolism of lipids acts as a fuel to support the tumour has never been clarified in detail and this discovery opens up new and unexpected scenarios in cancer therapy.
"We have identified a number of pharmaceutical compounds that selectively inhibit -- in different experimental models -- the mitochondrial enzyme responsible for the tumour growth, thus limiting fat synthesis and without harming normal cells." "I would like to point out, however -- concludes Alimonti -- that our discovery does not imply that cancer patients must undergo a strict dietary regime, which might in fact hurt them: a reduction of fat in cancer cells can only be obtained by blocking the cancer cells metabolism through specific drugs.

Not sure how to post the link, maybe paste into address bar.

https://www.sciencedaily.com/releases/2018/01/180115121635.htm

Post Edited (mr bill) : 1/16/2018 6:41:20 AM (GMT-7)

Done.

/www.sciencedaily.com/releases/2018/01/180115121635.htm

thank you --- 81G NEPOL

81,
I just had to try it.

[/www.sciencedaily.com/releases/2018/01/180115121635.htm

Looks like it worked. One more thing to add to my vast knowledge of computer stuff.

Post Edited (mr bill) : 1/18/2018 7:55:06 AM (GMT-7)

The title of this thread is “Warburg effect”. Therefore I would like to mention an alternative treatment whose rationale is based in part on the Warburg effect. There is a French physician, his name is Laurent Schwartz, who developed a treatment that targets the cancer cell metabolism.

This treatment, named Metabloc, consists of a combination of lipoic acid (ALA) and hydroxicitrate (HCA) plus Capsaicin. In some cases Dr. Schwartz adds Metformin and Chloroquine to that. Here is a link to one of his publications regarding this treatment and here and here are additional ones.
 
I know a castration-resistant PCa patient on ADT who added the Metabloc treatment to that. He uses 1200mg HCA, 450 mg ALA and 0.8 mg Capsaicin distributed over the day.

Metabloc stabilised his PSA value for about one year, with ups and downs though, delaying the need for Zytiga. Now he added 1000 mg Metformin and his PSA value declined by about 50%.
Another patient took Metabloc using the same combination because he had a rising PSA value after salvage radiation. He had no ADT. He observed that his PSA value stabilised for about a year.
So it seems that some patients may be able to delay the progression of the tumor this way. I know of some patients with a more advanced tumor where it did not work.
 
This is an alternative treatment and the observation of two patients only. Metabloc is applied before or adjuvant to a systemic treatment. It will not work as a last resort.
 
George