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Benign Tissue causing PSA Rise ??

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Posted 3/19/2012 7:55 PM (GMT 0)
Update-   I had my appointment with my URO/Surgeon this morning and we went over my recent 3 mo PSA results and he had a big smile on his face.

We discussed what a PSA of .157 meant for me right now. He explained that this was good, my high was .19 and my low with Avodart was .154 and now, 3 months off Avodart it is .157. He said that it takes about 3 months for Avodart to completely leave your system so he expects my PSA to still rise a little but he really believes it will stay below .2

We also discussed that if a surgeon spares the nerve bundles that even more benign tissue will be left behind. So the key to all this is that my gleason score was 6 and he saw no signs of cancer outside my prostate and he left considerable tissue behind from the surgery which is now generating PSA, so we are now trying to establish a new baseline and my next 3 month PSA check should do that.

For right now, I am very encouraged by these results and the explanations make sense to me.

Curt

Posted 3/20/2012 2:02 AM (GMT 0)
Hi Trimix,

I am also trying the Avodart experiment, although, as you can see by my signature, my PSA is quite a bit higher than yours. I started the Avodart at the end of Jan 2012. My next PSA is mid-April. Hopefully, this will give me a hint as to how much of the PSA is being generated by tumor and how much is being generated by benign tissue (if any). This will provide a better indication of whether I should start SRT.

Best of luck to you going forward,

TB
Posted 1/23/2013 5:25 AM (GMT 0)
Trimix,
Just saw this thread. My research shows some serious problems associated with both Avodart and Finesteride. How are your PSA numbers now and are your still on either of these drugs. Thanks.

Bob P.
Posted 1/23/2013 5:32 AM (GMT 0)
Hi Bob- No, I was only on Avodart for a short time, my PSA has leveled off now for some time.

Curt
Posted 1/23/2013 2:47 PM (GMT 0)

Bob P. said...
Trimix,
Just saw this thread. My research shows some serious problems associated with both Avodart and Finesteride. How are your PSA numbers now and are your still on either of these drugs. Thanks.

Bob P.

Hi Bob- I only took Avodart for 22 days to confirm that the elevated PSA we were seeing was from Benign prostate tissue that the surgeon left behind after my RP.

Now after some time and when the Avodart was finally out of my system, my PSA has leveled off at about an average of .25....I am having PSA tests every 30 days to watch the trend very closely.

So far, what my surgeon had told me and believes has been proven true for the short term, only time will tell the long term.

At this point, we are considering a PSA for me at .25 as my new baseline and if and when I would go up to .4.....we would then pull the trigger for SRT.....ugggg

Cheers,

Curt
Posted 7/12/2019 11:13 PM (GMT 0)
Hi, I'm new to this group/site. I read several threads with/from a person called Trimix (Trimix, if you're out there, I'd like to hear from you) regarding "Benign Prostate Tissue that may be causing a slight rise in PSA". This topic is what got me interested in joining this site. Quick history, diagnosed April 2018 at 54 YOA with PC: 4 out of 12 cores positive (Gleason7 (4+3) on 3 cores and 3+4 on the other 1 core.) Bone scan and body scan both negative. June 2018, Robotic Prostatectomy done, pathology report indicated negative margins, negative lymphs (14 taken), negative seminal vesicles, bladder neck, PNI & EPE...all negative (Gleason 4+3=7). My first two PSA's taken were <0.1 done August 2018 and November 2018. Then, the next two PSAs done Feb & May 2019 have been 0.1 (no < sign). Surgeon says still not considered a recurrence unless it goes to 0.2. I've even had a consult at MD Anderson in Gilbert, AZ, and they say the same. So, does anyone have any info/experiences on "benign Prostate Tissue" causing a rise in their PSA, without having a cancer recurrence.
Posted 7/12/2019 11:46 PM (GMT 0)
Hi Sunnydog- I am still here now after 8 years since my RP and my uro says I still do not have a recurrence of cancer....just the very slow rise every year of my PSA as my benign prostate tissue volume continues to naturally increase with age.

There have been several people on this forum that doubted my situation and I am happy to say in my case my uro has been correct so far.

I recently had kidney stones and my uro did an ultrasound of my kidneys and prostate area and said he saw nothing unusual.

I just had my annual PSA test and after 8 years it has had a very slow rise and is now .40

I am here to help anyone that feels they might be in the same situation....everyone is different and what happened to me is just my own personal experience.

Everyone needs to get involved in their own case, get educated and ask lots of questions.....in the end it is only your decision on what to do.

This forum has been a great place to share and get educated.

Cheers from Trimix....8 years out from RP !!!
Posted 7/12/2019 11:52 PM (GMT 0)
Sunnydog- Did your surgeon have an idea about how he removed your prostate....did he leave prostate tissue behind for the same reason mine did ?? Seems like reading your case that he could have done the same thing as my surgeon.

I asked a lot of questions and if you read my posts they are pretty well documented on this thread.

Cheers !!!
Posted 7/13/2019 3:29 AM (GMT 0)
Trimix,

That's great news on 8 years out. I've read about how PSA can show up after nerve sparing surgery due to tissue being left behind. I'm hoping that is the case with me. Thanks for the quick reply. Your thread really got me looking into the possibility of benign tissue causing the rise in PSA. With your current PSA level, how often do you have your PSA checked?
Posted 7/13/2019 4:19 AM (GMT 0)
For those hollowing this: Watch When recurrent PSA is not cancer, by Dr Myers dated 2012
Posted 9/3/2019 4:52 PM (GMT 0)
Trimix,

Hello again, I wanted to ask you about your Avodart rx...what dosage were you given by your doctor? I read your prior threads and it all makes complete sense (the the re-connective blood supplies that take place during the healing process). After moving from <0.1 to 0.1 in Feb 2019, I stayed there until just recently (August 1st) when most recent PSA went to 0.2. MD Anderson RO, as well as local cancer center wants to begin radiation (that's what they do), my surgeon wants to wait/hold tight to see a trend. With my post surgery path report (which I posted on my July thread), I'm having a hard time believing a recurrence, especially after finding out about how benign tissue can remain even mo so, after robotic surgery and verve sparing surgery, which was my case. Do you have any additional links that you can refer me to on this, I'm always interested in reading more...thank you!
Posted 1/8/2020 4:06 AM (GMT 0)

Sunnydog said...
Trimix,
Hello again, I wanted to ask you about your Avodart rx...what dosage were you given by your doctor? I read your prior threads and it all makes complete sense (the the re-connective blood supplies that take place during the healing process). After moving from <0.1 to 0.1 in Feb 2019, I stayed there until just recently (August 1st) when most recent PSA went to 0.2. MD Anderson RO, as well as local cancer center wants to begin radiation (that's what they do), my surgeon wants to wait/hold tight to see a trend. With my post surgery path report (which I posted on my July thread), I'm having a hard time believing a recurrence, especially after finding out about how benign tissue can remain even mo so, after robotic surgery and verve sparing surgery, which was my case. Do you have any additional links that you can refer me to on this, I'm always interested in reading more...thank you!

Hi Sunnydog- Here is an update on my situation....I have been on a yearly PSA test for some time and over the last 9 years it has risen very slowly....it has gone from.06 just after my RP to .4 last June.

I spoke with my urologist about this and he still feels it is just my prostate tissue that he left behind and slowly growing in volume that is causing my PSA to slowly rise over time.

We decided that I would go back on Avodart for 30 days and see how it changes my PSA...if my PSA drops back down to .10 like it did last time I did this, it will confirm that there is no cancer, but just the tissue causing the slow PSA rise over time....

Just after a week, my PSA had already dropped to .30....the peak of the avodart effect will be at 90 days and I will post the results then.

Cheers,
Curt
Posted 1/8/2020 4:11 AM (GMT 0)

Sunnydog said...
Trimix,
Hello again, I wanted to ask you about your Avodart rx...what dosage were you given by your doctor? I read your prior threads and it all makes complete sense (the the re-connective blood supplies that take place during the healing process). After moving from <0.1 to 0.1 in Feb 2019, I stayed there until just recently (August 1st) when most recent PSA went to 0.2. MD Anderson RO, as well as local cancer center wants to begin radiation (that's what they do), my surgeon wants to wait/hold tight to see a trend. With my post surgery path report (which I posted on my July thread), I'm having a hard time believing a recurrence, especially after finding out about how benign tissue can remain even mo so, after robotic surgery and verve sparing surgery, which was my case. Do you have any additional links that you can refer me to on this, I'm always interested in reading more...thank you!

You asked the dosage of Avodart...he put me on .5 mg for 30 days.

How are you doing BTW ?

Cheers,

Curt
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