A couple of new Breakthroughs?

A couple of new Breakthroughs?
https://medicalxpress.com/news/2019-11-driver-deadly-prostate-cancer.html

https://medicalxpress.com/news/2019-08-prostate-cancer-treatment-concept.html

THANK YOU FOR THE INFO. always good to hear good news ... have a great day NEPOL...

I agree mattam about CR. I thought I read or was told that every one of us EVENTUALLY becomes CR.

RCR,
Keep in mind that adding Xtandi, as well as early Chemo, has been shown to be equally effective to early use of Zytiga. Basing a treatment decision on one research paper may not be wise. I’m still very comfortable having chosen Xtandi for reasons which I did. I’m not trying to sway your choice, but encouraging you to keep these things in mind. It would interesting to see your MOs view.

Thanks for the advice mattam and Argent. I understand your reasoning and thank you for sharing that. unfortunately, I find myself in a bit of a hyper vigilant state at the moment with all that’s gone on recently. I’ve made some bad choices, “listening to my Uro” for one, when the studies came out about Adjuvent radiation after surgery with high risk cases such as mine. He dismissed that study and my request for a referral to an RO. Now we know I should have fired him and gone that route elsewhere. Well, that’s water under the bridge now, but for whatever reason I’m afraid of making more mistakes so when I read studies such as this one I’m easily swayed.

I did meet with my MO yesterday and we had a great talk. He respects my desire to learn and know but he tells me I’m unusual because most of his patients don’t want to know. I see the double edged sword here. Anyhow, he gave me a crash course in neuroendocrine differentiation. He believes we’re seeing more of this lately not because the drugs are causing it but because guys are living much longer with these newer drugs and given the longer life, the cancer has more opportunity to develop into that very virulent and devastating form. He explained its more like it morphs into small cell carcinoma as if it were lung cancer but doesn’t respond as well as the usual small cell drugs used to treat lung cancer. They just don’t know why it happens or how to stop it.

That said, we went on to discuss my brain MRI which was surprisingly was fine for Xtandi; however, another issue came up regarding my out of control hyperlipidemia (I’m allergic to all statin drugs)) He was actually more concerned about my choice of Xtandi and the cardiac risks with very high LDL cholesterol (around 300) so ultimately we did decide to reverse course and go with the Zytiga and pred. vs the Xtandi. I am a drinker and hopefully the liver will hold out. If there are issues tolerating Zytiga we will shift to Xtandi. The pharmacy will ship on Monday and I’ll start on it right away. I’m also still doing the two week Casodex regimen before I get my first ADT shot on the 25th. Thanks again for the advice.

The cardiac risks of ADT has it’s own controversy. I don’t think anyone really knows what’s going on half the time. Lol

Zytiga will work just as well as Xtandi. The important thing is you have a good plan in place.

Good luck ahead!