Looking for anyone or anyone that knows someone with a post RP low but rising uPSA level?

I’d just like to add to the comments above that there are guys whose PSA is not a reliable indicator of disease progression. I first heard that from an MO at Moffitt in Tampa when my PSA rose to 0.1 post RP. At 0.1 a bone scan revealed a pelvic bone met; however, docs were quick to assume it was not PCa due to such a low but rising PSA and sent me home for SRT. Fast forward and post bone biopsy with false negative results ...they were wrong. It Initially took almost five years post RP to get to 0.1 and then, post SRT, PSA started rising with a DT of six months. Another scan revealed a second met and it was concluded that I’m one of those guys whose PCa just doesn’t produce much PSA, thus unreliable to base treatment decisions upon. Apparently, this isn’t as rare as one might think. For the majority, PSA is a reliable indicator of disease progression, but not for everyone. uPSA testing is controversial in that numbers so low are also unreliable to base treatment decisions upon and may cause much undue anxiety. Additionally, my MO informed me that there are blood tests that were once used in cases such as mine but unfortunately are no longer covered by Medicare or commercial insurance. Nice... Glad to hear you found a good MO and best of luck in your treatment.

Afni,
Well, I think your consultant is probably correct. You likely are having a recurrence with a PSA doubling time of 12 months, so you have a ways to go before ADT is necessary. The big question is when to start ADT for post RP/SRT recurrence. It is an area of controversy. Some men likely start ADT way earlier than necessary. If your consultant isn't a medical oncologist, I suggest you find an MO experienced with PCa.

Good luck!

Obsession and anxiety over microscopic uPSA can fuel inflamation, and cause a lot more 'damage', than the rising uPSA. One reason many doctors don't recommend the ULTRAsensitive test to begin with.

Moderation, my brothers!