Screwy test results over time

I've copied my updated history below for easier access.
As you can see, my PSA has wildly gyrated in strange fashion over the last 10 years with a spooky big jump currently.
You'll note the two Biopsys show minimal/no disease.
The MRI last year showed nothing (PIRADs 1) except a huge and growing Prostate volume. 94cc's, can anybody beat that?
Anyhow, at that point, the generally increasing PSA was logically attributed to prostate enlargement.
The result received today was a bit of a surprise. The Urologist suggests retesting in a month.
Assuming it doesn't get better, what are your thoughts and suggestions?

Thanks,
Carl (age 73)

11/10 2.44
1/12 2.36
12/13 2.94
12/14 4.31
4/15 4.18
Biopsy 1/18 cores 5% Gleason 6. Went septic, 2 days of chills and high fever, scary.
Volume 66cc’s
4/16 6.68
Biopsy 3/18 cores HGPIN NO Sepsis
12/16 3.89
5/17 5.38
11/17 5.99
11/18 3.70
4/19 7.03
3T MRI with Contrast-“No suspicious lesions” PIRADs 1
Volume 94cc’s
8/19 4.38
5/20 10.2

No ideas but that sounds like an unusual sized prostate so maybe unusual PSA’s? Sounds like it might be biopsy time again since the last one was a couple of years ago and your PSA is at a new high. Maybe a consult with a top notch urology department, Roswell Park maybe if you are not going there.

I like the retest idea, that your urologist mentioned.

You have everything to gain, by staying on top of trends and fluctuations --- including troublesome infections and inflammation.

You're right --- if I was to graph your PSA over time, it would definitely show "peaks, then valleys" --- every fellow here likes the valleys much better.

Are you experiencing any issues or side effects, day or night?

Havd you ever tried a round of antibiotics, such as CIPRO, to see what impact that may have? That's a common "first step" ---

Keep us posted --- let us know what your urologist advises!

With my best,
Cyclone - # Iowa State University

Great news!