The Old Sailor strongly recommends a saturation biopsy (usually about
25-30 specimens). Very easy because you get general anesthesia, much easier than an in office biopsy under local anesthesia. I had 4.5 in 9/08 followed by a 10 core biopsy, all negative Then in July 09, 5.6 followed by saturation biopsy which found 5 of 28 Pca, 2 were gleason 8! Research shows (my surgeon pioneered the saturation biopsy) that nearly 45% of men with rising psa and previous negative biopsies are found to have cancer on saturation biopsy because the saturation biopsy goes through the perineum vice rectum which gives the urologist a template on the prostate and gives him the exact
location of the cancer if present. I had RRP on 13 Aug. Doing fine now but never knew I would have cancer if relied on regular biopsies.