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Tidbits stuff from PCa meeting I went to, HT hot flushes options & Bone density info Dr. Yu video

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Posted 1/12/2011 2:31 PM (GMT 0)
First off about HT androgen deprivation therapy and getting hot flushes, sweats, hot flashes:

Things that might work for a patient:

Megace

Megestrol

Cyproterone acetate

soy products ( ???) still some questions on proof

Gabapentrin

Zoloft  and  Effexor (anti-depressants can work):  Dr.  Yu is using  3.75 mg. (Effexor) of this in some patients and has found they got results  (go figure).

Provigil can help to fight fatigue with using HT  redface -----------------------------------------------------------------------------------

Bone density info:

Fosamax  (we know about)

Zometa or zolendronic acid I.V., there study had 5% density improvement shown within 12  months.

Alendronate  showed a 5% denisty increase also

Toremifene  80 mg. increased BMD, bone density but is non-FDA approved currently

Denosumab  showed a 6.7% increase at 24 mos. (subcataneous useage) non-FDA still

  also it showed 62% reduction in vertrebrate fractures over 36 mos. time

Other onco-docs he worked with on such studies,  C. Higano and R. Montgomery

(Dr. Yu is at Washington Univ. Hospital)  looks much younger than he actually is!  tongue

Posted 1/16/2011 4:42 PM (GMT 0)
Bump and pumped for newer readers to know, just in case it helps someone. These newer bone density drugs are going to be important and some will likely get approved or available.
Someone in my prostate group mentioned that he knows of some people getting things that are non-fda approved (just yet)...but found possible way(s) to get them, might include politics or wrangling, a name was dropped but decided I better not mention it here, some of us would know the name. He has gotten some patients a drug that was non-fda approved and from the manufacturer, maybe not real often but has happen.....heard it throught the grape vine...believe it to be the case. Just like Dr. Scholz and Lam have a deal with Johnson & Johnson to use Abiraterone, which in non-fda approved just yet. Patients are getting it right now and this was mentioned in Paact Newsletter.

 

Post Edited (zufus) : 1/16/2011 9:45:06 AM (GMT-7)

Posted 1/16/2011 4:52 PM (GMT 0)
zufus - the things mentioned by your for hot flashes, can I assume they would probably work for women in menopause with hot flashes? Or is that a different animal?

David
Posted 1/17/2011 12:24 AM (GMT 0)
<can I assume they would probably work for women in menopause with hot flashes?>

Yes.

<Or is that a different animal?>

No.

What worked for me was time - about 6 months.

Mitch in SC



 

Posted 1/17/2011 12:37 AM (GMT 0)
celexa worked for me.  i didn't have hot flashes until the expiration of my last shot of lupron, and i would say they are moderate in strength.


ed

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