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Posted 3/16/2012 4:05 PM (GMT 0)
AT 10 months post RP, I asked my Uro for trimix.  He said he preferred prostaglandin - because it had less chance of causing an emergency room visit.  I've now self injected 3-4 times; still experimenting with dosage, and am now at about a 85-90% erection for 45 minutes.  At an hour and a half, it's down.  All seems pretty good.  Cost is about $6/shot.  Within 2 weeks of my first shot, 2 friends in our same boat also got theirs.  One doc shot with trimix, and the other with alprostadil (sp?).  Both had 3-4 hour erections, and the trimix guy has had to shoot himself with the antidote more than once (he's a doc himself - so no emergency room for him).  Since I seem to be doing fine, this scares me a little re: trimix.

Questions:  What's the difference in the 3?  What's the advantage of trimix over the single drug?  Why the 3 different approaches - 2 of the docs are in the same clinic.  Should I ask the doc to make the switch?  At the rate I'm going, my PG prescription will last for years!  Next uro visit is 6 months.

And PS - to echo the others, for those fighting the ED battle, don't wait.  The shots are no big deal.

Posted 3/16/2012 5:40 PM (GMT 0)
CuriousG:

Questions: What's the difference in the 3? What's the advantage of trimix over the single drug? Why the 3 different approaches - 2 of the docs are in the same clinic. Should I ask the doc to make the switch? At the rate I'm going, my PG prescription will last for years! Next uro visit is 6 months. said...

Hey that was a very good question about WHY docs always say that they preferred plain old Alprostadil For Injection (that is the way it is sold in non-Edex form) instead of Trimix for Injection.

It took a little digging but I found that the Half-Life of Alprostadil is 5-10 minutes (but obviously once its effect has started it keeps on going for quite a while) but the half-life for Papaverine is 30mins to 120 mins. That has got to be the main reason why Trimix is more like REAL Rocket Fuel and can get out of hand/overdosed more easily.

Also Alpros/PGE-1 is a naturally occurring molecule in our bodies but Papaverine and Pentolamine are completely artificial creations -- so the body obviously knows how to handle the PGE-1 but not so much the other two. (Please note that all PGE-1 that is sold is a created product too -- but is the same as the naturally formed molecule).

J
Posted 3/16/2012 8:00 PM (GMT 0)
Hey JS - thanks. Guess all that makes sense. My doc buddy and I have discussed a small swap meet - TM for PG. Might be interesting.
Posted 3/16/2012 10:53 PM (GMT 0)
George -- Alprostadil is a variant of prostaglandin, so I think they are similar. Trimix is a combination of prostaglandin, papaverine, and phentolamine. One of the advantages of Trimix is that over 90% of men get results, whereas only around 60% get results from prostaglandin. Another advantage is fewer men experience pain with Trimix. Some men are more sensitive to prostaglandin causing penile pain after injection. This is less likely with Trimix since there is a much lower amount of prostaglandin in the medicine. Men that experience pain with Trimix can switch to Bimix, which is papaverine and phentolamine without the prostaglandin. Another reason Alprostadil may be prescribed is it is more readily available, has some insurance coverage, and is pre-filled.

Sounds like you are getting good results with the prostaglandin. You just need to tweak the dose a little. As long as you don’t experience pain I can’t think of a reason to switch to Trimix.

I use Trimix and have never been to the ER and have never had to take Sudafed, so as long as you are careful, getting your dose right it’s not a problem.

Good luck.
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