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Decipher Test

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Prostate Cancer
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Posted 12/12/2014 4:24 AM (GMT 0)
Has anyone had the Decipher Test done to test aggressiveness of PC. My husband got his results which are 8.9 percent. Average risk is 6 percent and high risk starts at 8.6 percent. Going to go talk to a RO but not until after the first of the year. Husband is not wanting to start radiation therapy until there is an increase in his PSA which is currently at .01. He is still trying to get incontinence under control and ED is an issue at this time. He doesn't want to do any more treatment until things are better. I am of the opinion he should hit this hard before it has time to grow. But at this time I cant convince my husband that he should. I think he is more afraid of the hormone blocking therapy more than the radiation. I am not sure what he should do at this time or how I can help him make a good decision.
Posted 12/12/2014 4:49 AM (GMT 0)
Cleveland Clinic just published a study on it. They found it to be a good predictor of metastatic progression after surgery.

A Genomic Classifier Improves Prediction of Metastatic Disease Within 5 Years After Surgery in Node-negative High-risk Prostate Cancer Patients Managed by Radical Prostatectomy Without Adjuvant Therapy.

Recent clinical trials demonstrated an advantage to adjuvant treatment over waiting to see. A recent analysis showed that a PSA≥.03 on an ultrasensitive test is a good predictor that the PSA will eventually hit .2, which defines a biochemical recurrence. So if he holds at .01, he is below that threshold for now. His positive surgical margin increases the probability that adjuvant radiation will be successful. His RO may let him forgo the hormone therapy if that is the deal breaker.
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