So true that PCa cells eat glucose just as does every other cell in the body. But I think the question to be looked into and settled one way or another is: can cancer cells survive on zero carbs or other than adequate or normal amounts of glucose? Normal cells absolutely can. We can go on a barely adequate protein ( high protein might get converted to glucose I think) and high fat diet and survive quite nicely, at least for quite a while. A well known example of a group that does that are the Eskimos of by gone days who lived of whale blubber for most of the year. Or so I have heard, I have never really hung out with them.
Also, Insulin is a related issue. Seems to me like I might have read over the years that insulin- especially excess insulin like so many of us produce- plays a big role in the growth of cancer cells. And if I understand it correctly, insulin spikes the more sugar/carbohydrates we take in, remains chronically high in that large group of the population with insulin resistance, folks who are also found in the population of Type 2 diabetics and pre-diabetics. I think most folks in those two groups have chronically high blood insulin, what with the pancreas working over time to produce it to handle a life time of high carbs. I think there are some brainy types out there who also relate excess insulin, and or diabetes, to cancer:
www.ncbi.nlm.nih.gov/pubmed/22840388www.ncbi.nlm.nih.gov/pubmed/25473296www.ncbi.nlm.nih.gov/pubmed/25488912 article said...
CONCLUSIONS:
Type 1 and type 2 diabetes are associated with an excess risk of incidence and mortality for overall and a number of site-specific cancers, and this is only partially explained by bias. We suggest that screening for cancers in diabetic patients is important.
EDIT: ironically, just about
the only cancer in this one study that was not made worse by diabetes, and in fact might have had decreased risk by diabetes, was prostate and melanoma! I'm on my way to the kitchen for some left over pecan pie!
I think (but don't know) these areas(high insulin/insulin resistance/diabetes) might be why metformin and berberine are thought by some to be beneficial in cancer treatment. I'm pretty sure that pancreatic insulin production plummets with extremely low/zero carbohydrate input. I'm also fairly sure that no amount of dietary fat(of any kind, saturated whatever) causes the body to produce insulin.
So, do we know that answer? Can cancer cells flourish, or even survive, on a very low carb/low insulin diet, like at least some people seem to be able to do? (some folks flourish with very low sugar- can cancer cells?) If so, does high- or even adequate- protein interfere with this possible benefit, by
opening a back door for glucose and insulin? Any good studies yet? I mean, I would hate to give up my pasta and other beloved carbs, but I would do it if my PCa was spreading and I thought there was a real good chance it would keep my cancer from killing me. I've done it before, the only thing that has ever succeeded at taking weight off of me. If I slash the carbs, even with more than adequate caloric intake(NO hunger) the fat comes off every time. I have a few friends this has worked for also, all while improving blood chemistry dramatically. I'm never hungry, but I do miss the tastes of some of my food addictions.
Now for my argument against this wonderful possibility. Our 40 year old daughter in law died from Mesothelioma a few weeks ago. 5 months after diagnoses. But a bit over a year ago she had weight loss surgery. She lost weight at a nice clip and was never hungry. I knew she had to be in ketosis due to miniscule carb input and no hunger, so we got some strips and measured. Sure enough, she was in major ketosis as expected. So most likely, as well as a very low blood sugar she also had almost no insulin output. The whole time, an undiagnosed cancer was growing inside her. We did not find out about
this until she could not stop losing weight beyond what she wanted, and developed some other symptoms: stage 4 at diagnosis. She was low carb( low everything really) until the day of her death. Low sugar didn't do jack s**t for her. And really, don't most cancer patients waste away? I don't think high sugar is the problem of most late stage cancer patients, is it?
Post Edited (BillyBob@388) : 12/15/2014 6:48:15 PM (GMT-7)