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MSK Nanogram for Remaining BCR Free

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Prostate Cancer
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Posted 5/6/2015 6:46 PM (GMT 0)
I'm a G7 upgraded from (3+4) to (4+3) after surgery. Out of curiosity I re-ran the MSK nanogram for my now (4+3) and was shocked by the results. There is a significant difference in likelihood to remain recurrence free between the two Gleason scores. Should I be considering additional treatment beyond the surgery before I would get a PSA rise? At 10 years it's darn near a 50/50. Uggh.


MSK Probability to remain disease FREE

---------- (4+3) (3+4) (3+3)
2 Year --- 88% 96% 98%
5 Year --- 72% 89% 96%
7 Year --- 63% 85% 94%
10 Year - 54% 79% 91%


Thanks for any input - Jon
Posted 5/6/2015 7:15 PM (GMT 0)
Jon,
That's a tough one. Never good to see an upgrade of one's Gleason. There is a world of difference between 3+4 and 4+3.

The real question is, was all the PC confined to the prostate. If yes, you're done. If no, you'll need more treatment. How to know? Watch the PSA numbers.

Should you treat before the PSA starts rising? Don't know. SRT would be the normal next step if you needed more, but I'd be tempted to wait for one more three month PSA test before deciding.

Also, are you getting th ultra-sensitive PSA tests? They should be able to see lower than .05, which might be meaningful in your case as the newer studies are suggesting SRT with a rise over .03.

Just my thoughts,
Andrwe
Posted 5/6/2015 11:42 PM (GMT 0)
"if yes your done" Lord if only that were factual or true!!
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