I'm Curious About a Few Things....

While on Lupron, Dan's bone mets have progressed and his PSA has dropped.
Should his testosterone level be checked to see if the Lupron is working?
Should they try another hormone drug?
Is the Lupron dosage the same for everyone?
He's 6'5" and 283. I've heard that women store estrogen in fat; do men store testosterone?
He's due for his second shot 6/13 and wondered if he should try something else or something additional. His PSA at the time of his first shot was probably around 60. It was 31 six weeks earlier and doubling about every six weeks. It has dropped to 3.6 after radiation. Would the mets produce a higher PSA or is this the Lupron working? He has had no side-effects at all from the ADT. No hot flashes, no nothing. Don't you know the doctors love to see me coming.
Thanks for any answers you can provide.

I had a couple of thoughts. If mets are truly progressing (more mets in same area or more areas of involvement?) with lower PSA, is neuroendocrine mutation a possibility? Also, if more bones are showing involvement then maybe xofigo?
Beth

Are you with a world class urologic oncologist that has demonstrated experience and success with high risk advanced cases? If in doubt, get to one.

I would have hoped for a greater drop in PSA than you have experienced. While I was a G7, I dropped from PSA 59 to undetectable in a little over 90 days on Lupron and Avodart. Also, he should have his T checked to determine if he has reached castrate levels.

Then there is the issue of whether another treatment should be introduced like chemotherapy. Also, is he screened for Provenge? I would have everything in order to go on at the very earliest opportunity.

G10 is as aggressive as it gets, the treatment should be more-so, in my opinion. Another member, JohnT, has often said that "low risk PCA is over-treated and high risk PCA is under-treated".

Best wishes,

Jack