negative biopsy but PSA 6.39

My biopsy in January was negative . Had a TURP done in Feb which helped my urine flow and again the tissue removed was negative , but the doctor is concerned that my PSA won't go down . Two taken in the last 2 months have been over 6 , latest at 6.39 . MRI is scheduled for next week . I have had what I thought was sciatic pain in my hip , buttock and running down my right leg for about 6 months . Now I am worried it could be cancer . Is this a possibility ?

No. It's an incredibly tiny, tiny possibility. Maybe you have a different cancer causing your pain, but extraordinarily unlikely it's PC. Most likely, you—like many (or all) of us here—are feeling some of the natural aches and pains of growing older, which comes with occasional herniated disks, osteoarthritis, etc. etc. Let doctor B help you explore that.

What's doctor A doing to address your elevated PSA? The AUA (American Urological Association) tells doctors that in non-symptomatic men they should try to identify and eliminate other causes of elevated PSA before conducting a prostate biopsy. (There's a lot of urologists who don't follow their professional association's guidelines, though.)

Here's some facts you need to know: 1) PC is only the cause of elevated PSA in about 1/3 of men; the rest are due to prostate infection and/or BPH. 2) PC is so common that it is considered a natural part of aging. Roughly 50% of 50 year olds, 60% of 60-year olds, etc have it...but most never know they have it and it will never affect their lives. Let that sink in. Those guys just never ran into the set of circumstances that led to a biopsy, which led to finding some amount of PC and being "diagnosed." Most cases "diagnosed" don't even need immediate treatment...only monitoring. As ubiquitous as PC is, now's the time to learn more about these and other important facts relating to this part of your anatomy which you've probably paid little attention to in the past.

good luck

The only way to confirm cancer is to examine the cells taken by the biopsy. This examination will also assign a Gleason score that shows how aggressive the cancer may be. As we age, PCa becomes a greater risk, but as JackH reports most men that have been diagnosed have a low grade variant that often requires no treatment. However, about a third of men, like myself, have a risk level that requires treatment and can be very dangerous. Thus you need to be diligent to determine what is causing the elevated PSA.