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Any sporadic SE's from Lupron after a year off?

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Posted 7/9/2017 12:46 PM (GMT 0)
In the dark days of my yucky Lupron side effects I was either cold and covering up or sweating - there was no happy medium. I should be free of SE's since the Lupron should have been out of my system a year ago.

Recently I've been sweating (in air conditioning) and last night I got cold and had to cover up - a horrible reminder of Lupron.

Has anybody had any long lingering/intermittent SE's from hormone treatment? My RO doesn't think that's possible but I know what I went through and how I feel.
Posted 7/9/2017 1:00 PM (GMT 0)
I sure have! Just like you said. I have had a low rate of hot flashes ever since my ADT2 ended March 2016. My measured testosterone level is now actually about 20% above my baseline, about mid-range for normal levels.

My MO has no clue either, "can't be happening". Yeah, right, well it IS. And as you said, I KNOW what they feel like, and it's not my imagination!

One theory I saw was that long term ADT may permanently change how your body uses testosterone. So, the recovered level is now actually too much!

Have you had your testosterone level checked? It's quite possible you still have a very low level.
Posted 7/9/2017 2:09 PM (GMT 0)
It took a good 18 months for my body thermostat to return to normal. How can any doctor that hasn't been on HT give us any real advice? Messing with the hormonal balance is a much bigger deal than most people and doctors understand

My early sporadic se was bursts of energy. Something I had little of while on HT.
Posted 7/9/2017 2:53 PM (GMT 0)
Thanks guys, at least I'm not the only one experiencing this. My T rebounded quickly which surprised the RO, at nine months after the injection I think it was 370 or thereabouts.

My energy level seems to be up and down sometimes also, now I'll attribute every anomaly to Lupron ; )
Posted 7/9/2017 5:00 PM (GMT 0)
John, you and I sound very similar. Almost identical recovery situation. Since your T is normal, as is mine, all we can really do is wait it out, it seems.

Oh, and i like to blame everything on Lupron too!
Posted 7/9/2017 6:32 PM (GMT 0)
John,

I have been off the eligard for a year now. Still having hot flashes. PSA is undetectable but Testosterone is only at 27.. MO says not abnormal. T should be back before too long. I was on it for 2 years.

Hang in there

Carl
Posted 7/10/2017 12:09 PM (GMT 0)
My understanding from my urologist is that the time release drugs like Lupron and Eligard have a half-life of the time period for the injection. So the 4 month shot has a half-life of four months. Further, small amounts of the drug in the system still have a T lowering effect. He explained that it takes three half-life cycles for enough of the drug to be washed out of the system for the T rebound and diminishing side effects. For me that was about 18 months after my last shot ran out. Thankfully once my T started moving it went fast and I got back in the normal range within about 6 months.
Posted 7/10/2017 3:05 PM (GMT 0)
Three half-lifes would put me at 18 months (or 24?) - so I suppose that explains some lingering SEs. My RO didn't ask for T with my labs last month but she's going to check when I return in December.

Thanks again guys!
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