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New Lu-177-PSMA ligand effective in German trial

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Prostate Cancer
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Posted 9/5/2017 6:38 PM (GMT 0)
I know there's great interest in the developing field of radiopharmaceuticals for advanced prostate cancer.

A new PSMA ligand called PSMA-I&T (Imaging and Therapy) was attached to the beta-emitter Lu-177 and used on 21 patients in Munich. It was used on 56 patients last year in Bad Berka, Germany. It seems to reduce PSA very well and has minimal toxicity. They are tweaking the molecule to improve results. It doesn't seem to be the best ligand for imaging, however.

/pcnrv.blogspot.com/2017/09/a-new-lu-177-psma-ligand-has-good.html
Posted 9/5/2017 7:26 PM (GMT 0)
Good to see other countries (primarily Western Countries) getting involved in finding / experimenting with new therapies. The more the merrier!
Posted 9/5/2017 9:48 PM (GMT 0)
Germany (particularly U of Heidelberg) has really led the way on this. The US is just starting to get on board, particularly Scott Tagawa at Weill Cornell. The trial in Houston is mega-expensive. MSKCC is running an interesting trial now too.

If it were me, I'd consider medical tourism. The guys at Heidelberg have more expertise than anyone else.
Posted 9/5/2017 10:11 PM (GMT 0)
Pardon me for a diversion. As a freshman in Chemical Engineering at Iowa State University in 1965, I was encouraged to go to a lecture by a guest speaker, "Ligands in blah, blah, blah". At the end of the lecture, I turned to my friend an asked, "What the heck is a Ligand?"

...Jerry
Posted 9/6/2017 12:13 AM (GMT 0)
Jerry - too bad you didn't have this article in 1965.
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