Posted 11/22/2017 3:19 AM (GMT 0)
Hello...it is MR123...I could not get back into the forum no matter what I tried...so...I needed to re-register...sorry for any confusion...
I wanted to sent this follow up and ask a few questions...
I received the results of my 4K blood test today. The Urologist told be I had a score of 7. I am confused with the way he is explaining the significance of the results. During our conversation he seemed to be indicating that I had a 7% chance of having a cancer (and a 93% chance of not having one)...and that I should consider a biopsy. On the 4K website it seems to me that having a score lower then 7.5 indicated a low incidence of cancer with the chance of developing metastatic cancer in 10-15-20 years as low (I think in the neighborhood of 1-2% from this test and at this time and place). Does the 7 above equate to an actual percent possibility of cancer or is this the Score...meaning...is it possible the Urologist is confusing the score with a percent possibility of having cancer at this time? Does the 4K score equal a percentage of probability? I though (from reading) that the scores from the 4K websites broke down as such:
4Kscore Test Biomarkers
> 7.5% (N = 1,510, 62%)
5 year = 2.4%
10 year = 5.6%
15 year = 9.9%
20 year = 16.4%
all men PSA ≥ 3
4Kscore Test Biomarkers
≤ 7.5% (N = 922, 38%)
5 year = 0%
10 year = 0.2%
15 year = 1.0%
20 year = 1.8%
RESULTS INTERPRETATION:
Based on the 4Kscore Test US validation study, prostate biopsy should be considered in most men
with a 4Kscore result of 7.5% or higher. Reference ranges are as follows:
• Low Risk: 4Kscore result <7.5%
• Intermediate Risk: 4Kscore result 7.5-19%
• High Risk: 4Kscore result ≥20%
Does the %'s above mean...
<7.5% is equal to a 7.5% chance or less of a cancer being present?
>7.5%-19% equates to a 7.5% to 19% chance of a cancer being present
> 20% equates to a 20% or greater chance of a cancer being present...
W H AT D O Y O U R R E S U L T S M E A N ?
• Low Risk: Your probability that the prostate biopsy will be diagnosed as
aggressive disease is less than 7.5%. Your risk for cancer spreading to other
parts of the body within 10 years is less than 0.5%.
• Intermediate Risk: (7.5-19%) Your urologist will evaluate the 4Kscore test
results in conjunction with additional clinical information to decide on
the appropriate next step.
• High Risk: (>20%) Consider prostate biopsy to detect aggressive
prostate cancer.
4Kscore has been shown to predict risk for distant prostate cancer metastases
occurring up to 20 years later from a blood sample in otherwise healthy
men who have PSA ≥ 2ng/mL. A population-based cohort in Västerbotten,
Sweden followed 12,542 men to determine their risk of distant prostate
cancer metastases. Results, as illustrated in Figure 1, show that a group of
men who had a 4Kscore of 7.5% or lower were found to have 1% chance of
developing metastatic prostate cancer by year 15.
Does the number 4K score go higher then 20%...again though...does this percentage translate into probability of cancer (20%=20% chance of cancer)?
Sorry for this long winded post but I am very confused with the way the results are being interpreted and then explained to me.
Finally...and to cut to the chase...with my bouncing PSA over the past couple of months...(4K PSA component of todays test is reported at 4.51 down from 5.4... 22 days ago)...my PSA Density of .07 and my PI-Rads 2 score of 2...and as well as my documented BPH would you feel that I am a candidate for a biopsy at this time? Thank you very much for any responses...
History:
Sept 11, 2016 1.6
Sept 11, 2017 2.3…and then 1month later…
Oct 12, 2017 … 5.6…and then 12 day later…
Oct 24, 2017 …2.5…and then 7days later…
Oct 31, 2017 …4.68…and then 10 days later (yesterday)
Nov 9, 2017 5.4...and now 22 days later....
Nov 21, 2017 4.51...this is the PSA number that was included along with the other values reported in the 4K results
3T MRI...
October 18, 2017 MRI of prostate
CLINICAL STATEMENT: Elevated PSA.
TECHNIQUE: Axial T1-weighted; axial, coronal, and sagittal T2-weighted;
and axial diffusion-weighted images were obtained.
1 mg of Glucagon was given subcutaneously.
COMPARISON: None.
CORRELATION: None.
FINDINGS:
PROSTATE MEASUREMENTS: 5.4 x 5.2 x 5.4 cm; volume 75.8 cc
TUMOR location(S): Ill-defined areas in the bilateral
Peripheral zone are nonspecific.
EXTRACAPSULAR EXTENSION: None.
SEMINAL VESICLE INVASION: None.
MEMBRANOUS URETHRAL
LENGTH: 1.2 cm.
PELVIC NODES: No adenopathy.
BONES: Unremarkable.
OTHER: None.
IMPRESSION:
1. No focal suspicious lesion. PI-RADS v2 score 2.