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Supplements....Part 97

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Posted 4/22/2018 12:48 AM (GMT 0)
I know many of us are taking OTC dietary supplements in the hopes they might have some positive effect on the monster we are all fighting..So here is one or two more for the list. I noticed there was a Clinical Trial in progress that was testing the efficiency of Grape Seed Extract. A refined version called Leuco Select. There must be something to it if they are going through the trouble of running a clinical trial on it...Can't hurt, right? Another supplement, Niacinamide sometimes called vitamin B-3 may not fight cancer but it seems to make you feel better, cancels out the side effects of some of the drugs we take....

In my case, the Zytiga and Xtandi reduced my RBC Red Blood Count to slightly sub-normal levels so I'm taking an Iron supplement to hopefully remedy that...
Posted 4/22/2018 1:09 AM (GMT 0)
"There must be something to it if they are going through the trouble of running a clinical trial on it"

All it takes to run a clinical trial is funding, which I'm sure the good folks at Leucoselect are providing. It is only a Phase 2 study, which isn't designed to prove an effect. There are dozens of such clinical trials and 99% will yield nothing useful. I'm sure you remember all the funding that Pom Wonderful put into pomegranate juice clinical trials - that ultimately showed "no effect."

Here's what I have in my files for grapeseed extract:

/www.ncbi.nlm.nih.gov/pmc/articles/PMC3100666/
Posted 4/22/2018 7:01 AM (GMT 0)
My view on dietary supplements are:
- OTC dietary supplements is not for treatment or prevention of diseases.
- OTC dietary supplements are only assessed for safety and NOT EFFICACY. (Efficacy is assessed only for drugs.)
- Side effects and interactions with drugs are not tested for OTC supplements and must threfore be regarded as "unknown".
Posted 4/22/2018 10:40 AM (GMT 0)
Here's my take on the supplement fight (it IS a fight, it has gone long past "discussion", "conversation", or "debate")

Most supplements won't hurt you. Some might give you a false sense of security. Some, particularly in combination with other supplements or prescribed medications, can hurt you. Some might have some therapeutic benefit (especially those that are the precursors to actual medications)-if they are used properly.

NO supplement or dietary regimen can CURE cancer. Some may boost your immune system and help your body deal with it. Some (all?) may give you a mental/emotional boost--which is more important than we can know.

When a researcher says, "we don't know", it's kind of like a judge at a trial who says, "beyond a reasonable doubt"--a very high standard of proof is required, it's very different from "we think it might, and it doesn't look like it does any harm"--which is good enough for most people.
Posted 4/22/2018 1:22 PM (GMT 0)
For those who do believe supplements are at least worth looking at, this website ($39.99 per year) is worth subscribing to.... www.consumerlab.com

They talk about which supplements/vitamins do what, they cite studies, they actually do test for content(does it actually contain what it says it contains), and they make recommendations based on content and cost.
Posted 4/22/2018 5:50 PM (GMT 0)

halbert said...
Most supplements won't hurt you.

There are thousands of supplements, and many of them don't even contain what is on the label, so you are probably right. But how do you know which are harmful and which are not without a randomized clinical trial? Imagine if we adopted that same lax attitude about other drugs (and supplements are drugs) manufactured by pharmaceutical manufacturers!
Posted 4/22/2018 7:34 PM (GMT 0)
Here is the grape seed trial...

/clinicaltrials.gov/ct2/show/NCT03087903
Posted 4/22/2018 8:55 PM (GMT 0)
Just read an article regarding the testing of supplements. Tall Allen is correct. Many of them do not contain what they advertise, or an amount that may have any benefit. Basically the article said that if they are to cheap to pass up, you probably should. Many contained soybean, crushed rice, etc. and not what they advertise on the label. Anything to make a buck. just be careful, especially with the imports.

Google fake supplements.
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