How long Zoladex injections, 1 or 2 years?

I am 77 years old and was diagnosed with early stage prostate cancer through a biopsy taken during a TURP in August 2016. During watchful waiting the PSA rose gradually to 10.3 by April 2018. A biopsy and PSMA PET showed that I had a Stage T3bN0M0 tumor (with a Gleason 5+3). I was given a Zoladex 0.8 injection on 30 April 2018 and received 25 fractions of 65 Gy radiation in July and early August 2018 Since then I have received 3 further Zoladex injections at 3 monthly intervals. My PSA came down and was most recently <.008 in March 2019 and also in April 2019. Based on this and an MRI in March 2018 December and a physical examination in the rectum I have responded well according to my doctors and show “no evidence of disease”.

The Zoladex injections however have been causing me more and more discomfort: considerable weakness, weight gain around the abdomen, swelling in the ankles and lower legs etc, hot flushes etc. Being an outdoors person and otherwise quite fit I have continued daily hard swimming throughout but find it more and more difficult to do the same length. Even climbing a flight of stairs is an effort.

I would prefer not to continue with the hormone therapy (for the recommended two years) as long as I am not taking an unacceptably high risk. Kindly advise.

G8(5 + 3) is kind of unusual, but what is important is the 5, which is the highest grade cancer cell type and the predominant cells in your biopsy. I agree that finishing out your ADT regimen seems the wisest path.

Good luck!