Obesity and Prostate Cancer

https://acsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32906?af=r Well I'm in the overweight category don't think I will ever be in the normal so am I in trouble? It's pretty small study and as we have said many times almost every study can be made to look the way you want it to. Just going from my experience at the hope lodge and at the mayo clinic most of the guys were in the normal to overweight category. We talk a lot about diet on the forum here thot this might be interesting.

Larry

Duck2 said...
“Data from 5929 patients who underwent RP and were in the Shared Equal Access Regional Cancer Hospital (SEARCH) database were analyzed”

“Neither overweight nor obesity was associated with risk of BCR, CRPC, or metastasis (all P ≥ .18).”

“Conclusions

Obese men undergoing RP at several Veterans Affairs hospitals were found to be at an increased risk of PCSM, regardless of race.”

Hopefully you avoided several VA hospitals for surgery, which ones is your guess.

...............................................................................................................................................................................

I am confused. Is there an association, or not?

On one hand, there appears to be an association between obesity and PC death: "obesity was found to be associated with an increased risk of PCSM (hazard ratio, 1.78;.......".

OTOH, "No interaction was found between BMI and race in predicting PCSM (P ≥ .88), BCR (P ≥ .81), CRPC (P ≥ .88), or metastasis (P ≥ .60). Neither overweight nor obesity was associated with risk of BCR, CRPC, or metastasis (all P ≥ .18)...........................................".


But bottom line:
"Conclusions

Obese men undergoing RP at several Veterans Affairs hospitals were found to be at an increased risk of PCSM, regardless of race. ". ?

Help me out, what am I missing? Can you die of PC without BCR and/or mets? I must be looking at this wrong.

However, the conclusion, of higher mortality being associated with PC mortality,would seem to align with older posts I have made about the 3 times worse worse outcomes with higher insulin(obese folks would tend to run high insulin) and 8 times worse for those with both the highest insulin and highest waist to hip ratio. Something like that. If indeed that is what this study is claiming.

Post Edited (BillyBob@388) : 6/10/2020 5:27:50 PM (GMT-6)

If one is obese it affects every aspect of your help...that's not a secret...why pick on Pca...does it really matter now...and if it does...lose the weight...folks do it all the time...no merci from moi on this on...our middle son lost 125lbs in a year and still losing...he looks and feels terrific...if can...can...if no can...no can...try tho...

Something that is almost always missed in these studies is they establish a correlation - which means 2 things show up at the same time - but not necessarily a causation which means that the 1 makes the other happen.

If you have a high BMI and are considered "obese" or "overweight", that does not necessarily mean that you are not healthy or that you are sedentary. Those are other variables that are often not considered when making conclusions.

While a high percentage of heavier individuals achieve that with a sedentary lifestyle and poor diet choices, there are those who eat sensibly and/or work out very seriously over extended time frames that also have a high BMI. Pro athletes immediately come to mind.

There is a well-known "obesity paradox" in PCa, e.g.:

Obesity Paradox in Prostate Cancer: Increased Body Mass Index Was Associated With Decreased Risk of Metastases After Surgery in 13,667 Patients (2018)

"Conclusion: We recorded the obesity paradox phenomenon in PCa patients. In particular, high BMI (≥ 30) was associated with decreased risk of metastases after RP, despite an increased risk being anticipated. Whether statin use might have affected the results was not assessed. Further research is needed to unravel the controversially debated association between obesity and PCa."

Effect of obesity and inflammation on prostate cancer disease risk and mortality among African and European American men (2020)

"Our primary analysis suggests an obesity paradox, where obesity may protect against disease mortality among the African-American men. In subsequent analyses, we will examine the role of immune and inflammation markers in mediating or moderating the observed relationship of obesity with PCa in these men."

Interestingly, it's also been found that men with BPH have a slightly lower incidence of high-grade PCa than that seen for men without BPH (unfortunately, I wasn't in that BPH cohort!). One hypothesis proposed is that the increased mechanical pressure on the prostate cells plays a role.

It should be emphasized that these studies do not endorse getting fat!!

Djin

I am therefore I think...the horse not des-carte