Sent in my genetic swab test

Some of the results may be in the form of "You have the xxx mutation on chromosome n, which gives you 1.5x risk of xyz." In other words, move that disease up on the list of things to rule out when you get symptoms.

Djin

Who will be doing the test?
Mine was done by INVITAE for a study conducted by Georgetown University.
Info from Georgetown U states
'Up to 17% of men with prostate cancer have inherited a mutation in a gene that is associated with an increased chance of developing prostate and/or other cancers'.

When biopsy samples are tested, mutations that occurred after you were born may be discovered as well.

DJIN,

" In other words, move that disease up on the list of things to rule out when you get symptoms."

Yes, self diagnosis is the bain of most internet doctors.

Impact of Pathogenic Germline DNA Damage Repair alterations on Response to Intense Neoadjuvant Androgen Deprivation Therapy in High-risk Localized Prostate Cancer (2021, Full Text)

"Abstract

Background
Intense neoadjuvant androgen deprivation therapy (ADT) before radical prostatectomy (RP) is an investigational approach to reduce recurrence rates in men with high-risk localized prostate cancer (PCa). The impact of germline DNA damage repair (gDDR) gene alterations on response to intense neoadjuvant ADT is not known.

Objective
To evaluate the prevalence of gDDR alterations among men with localized PCa at high risk of recurrence and evaluate their impact on response to intense neoadjuvant ADT.

Design, setting, and participants
We performed germline panel sequencing for 201 men with intermediate- and high-risk localized PCa from five randomized multicenter clinical trials of intense neoadjuvant ADT before RP.

Intervention
Intense neoadjuvant ADT followed by RP.

Outcome measurements and statistical analysis
The prevalence of pathogenic gDDR alterations and their association with exceptional pathologic response (complete response or minimal residual disease, defined as residual tumor with the largest cross-section dimension ≤5 mm) to intense neoadjuvant ADT and rates of post-RP biochemical recurrence.

Results and limitations
Pathogenic gDDR alterations were detected in 19 (9.5%) of the 201 PCa patients. The most frequently altered genes were BRCA2 (n = 6; 3.0%) and ATM (n = 4; 2.0%). Patients with gDDR alterations exhibited similar rates of exceptional pathologic response (26% vs 22%), pT3 disease (42% vs 53%), lymph node involvement (5.3% vs 10%), extraprostatic extension (35% vs 54%), and positive margins (5.3% vs 13%) to patients without gDDR alterations (all p > 0.05). The 3-yr biochemical recurrence–free survival was also similar at 45% (95% confidence interval 7.9–78%) for men with gDDR alterations and 55% (95% confidence interval 44–64%) for men without gDDR alterations.

Conclusions
gDDR alterations are common among men with intermediate- and high-risk localized PCa. Men with gDDR alterations appear to have a comparable response to intense neoadjuvant ADT to that among men without gDDR alterations and should not be excluded from consideration for this treatment approach.

Patient summary
Intense therapy to inhibit the production of androgen hormones (eg, testosterone) before surgery may minimize the risk of cancer recurrence for men with high-risk localized prostate cancer. Inherited mutations in certain DNA repair genes are associated with particularly high rates of recurrence. We found that men with these mutations respond equally well to this intense androgen inhibition before surgery as men without the mutations."

[Emphasis mine]
____________________________

The prevalence of germline mutations appear to be greater in high-risk, localized PCa. It also appears that even if the incidence of any one mutation may not be very large, there are many that are possible, and together the percentages add up, even for men in lower risk groups.

Djin

My genetic testing was by Invitae and covered 21 genes associated with prostate and breast cancer such as BRCA1, BRCA2… Results were sent to genetic counselor who sent a long summary report with the results to me after phone call. Nothing of interest found.