I switched from Asacol to Lialda at the end of August '07. I take 2 pills (2.4 GM) once a day. Before I switched I had blood in my stool (this was my only symptom of UC @ the time) and after being on Lialda the blood completely went away within a matter of a few weeks. I think the reason Lialda helped me is because with the Asacol I was never consistently taking the pills b/c i was suppose to be taking them 3 times a day and I would always forget. Also, Lialda is suppose to reach further down in the colon then Asacol so this could also be why it helped me more. I haven't noticed any side effects or problems w/ Lialda.