Imuran stopped working?

I imagine that with the right catalyst and stars aligning that you can bust through any drug - I was on asacol for months and was doing fine and then I broke through it like the Kool-Aid pitcher guy comes through walls. I was taking 12 a day at the time and it came so fast and so hard that I was actually passing the asacol for 3 weeks - they didn't digest at all.

Imuran stopped working for me.  I started on 75 mg / day in May 2007 and started to flare in early September.  In between, however, I felt great.  My GI increased my dose to 100 mg / day this past June because I was having difficulty achieving remission with other meds and I have felt pretty good since (Imuran does not reduce aching / inflammation in joints for me).  I feel like I am now playing a waiting game - waiting to see if Imuran stops working again.

I have been on 6mp for almost 2 years. I would have to say that it did a fairly good job of keeping me out of severe flares but I was flaring nonetheless (albeit more mildly) even after dosage increases. My GI has performed a couple of Prometheus Metabolites test and even after dose increases, the number never went up. He pretty much said that my metabolism is not working right so I can't get the best use out of this med. He won't increase my dose anymore because it just won't work and it could become toxic to me. I have come to the decision that I want off these meds and I plan on bringing up surgery when I see my GI next week. But yes, I do believe that you can become tolerant to the med and your body doesn't respond as well to it over time. Have you had any Prometheus testing lately?

This is a test they send to Prometheus labs to see how you are metabolizing the medication. If you have never had this done before, ask your doc to do it. But I wouldn't recommend it until you clear it thru your insurance company to see if they will cover it because it can be costly.