I know about
current research regarding the genetics of IBD Subdued, I'm a member of the CCFC and get journals throughout each yr with updated and current info and researchers do believe there is a genetic predisposition of getting an IBD (either CD or UC), what they are not clear on is how it's passed down because it's more complex compared to cycstic fibrosis for example where there is a single gene defect involved and the pattern of inheritance for CF is such that the affected person must receive 2 defective genes, one from their father and one from their mother. But in IBD it appears that many different genetic defects may be simutaneously necessary to produce the disease...the mathematical pattern of inheritance that is the case with CF is simply not known in IBD. Which is why researchers say that it has been estimated that if one parent has an IBD there is a 10- to 15- fold increased risk that your offspring will also develop an IBD compared with those who do not have a parent with IBD. And that's not saying that only those with a parent that has an IBD are the ones that are genetically predisposed to likely getting an IBD either.
Even though much remains unknown about
the cause of IBD, most experts agree on a basic framework that explains why people develop CD or UC. In essence, the cause of IBD lies in the complicated interactions that occur between the genes that IBD patients are born with, environmental factors and the ever-present challange of bacteria that live in the intestinal tract.
DNA is organized into genes that encode all of the instructions required to build and maintain living organisms. Genes determine physical traits such as eye and hair colour and height. Genes also program the body, for example, cells of the immune system are under the control genes that determine the strength, effectivness and appropriateness of an inflammatory response. Genetic infulences have long been suspected to play a role in IBD based on the following clues. 1) certain ethnic groups are at substantially higher risk for IBD than the general population. 2) there are extream cases of familial IBD where nearly every family member suffers from the condition. 3) in studies of identical twins, if one twin has CD there is a 40-60% chance the other twin will also have the disease.
If you don't agree with the above statements then you're disagreeing with one of the lead reseachers of the genetics and inheritance of IBD in Canada, who I happen to believe because he's going by scientific facts, not by "well I'm the only one that has it" which should be obvious by now, that could simply mean that other family members have not had theirs triggered yet, just as many people that were predisposed to having an IBD may have lived their whole lives without being affected by the disease simply because it was not triggered for them...you are not thinking out of the box, you assume becasue no one in your family had/has it that you're the only one so it's not genetic...and I guarantee you do not know everyone of your past family members health histories, especially their bowel health because people were shunned for discussing such things way back when and just because you have an "
open family" now doesn't mean every family member from the past was
open about
things, especially poop things.
I'm not the one being closed minded about
it and I do have the facts according to current and past research and how on earth could you even explain how someone gets an IBD without being genetically predisposed to it??? It's not like herpes or other STD it's a genetically predisposed disease. Which by the way was confirmed once again yesterday when I was watching the local news and they did a story on the "health beat" about
a UCer and how he has a video on you tube about
his UC and the GI in the story even re-confirmed that "in order to get UC, one must be genetically predisposed to getting it and triggers are involved with setting the disease in motion."