My first infusion I had a reaction. They gave me benadryl and I was out of it and I felt weak (like I had the flu). My second infusion they premedicated me with tylenol, and hydrocrotison. I was fine during the infusion but after I felt weak and tired. My third infusion they premedicated me with the same stuff and I was fine. I take all day with my infusions because I have a reaction so they do mine very slow. I get there at 9 and I'm usually not done until 3-3:30. I get chest pains so they don't want to go any faster. I guess it depend on how you respond to the infusion. Good Luck.