A question for those who can't tolerate Mesalamine

I've been taking Mesalamine in the form of Salofalk enemas and Mezavant for about 6 weeks, and it seems to work ok. Unfortunately it aggravates a peripheral neuropathy issue I've been dealing with. If this PN escalates, then I guess I will be forced to discontinue. So my question is whether there is another form of 5 ASA that may be more tolerable.

Also, what form did your problem with Mesalamine take, and if Colazal is more tolerable, how does that work, since they're both 5 ASA? It would be nice to stick with 5 ASA if at all possible, since it works after all, and I don't think I'm going to have much luck with steroids or immunosuppressives, due to liver issues.

Hey Thinker,
Have you heard of Osalazine (dipentum) ? It's another type of 5AHA but good for anyone allergic to Sulpha. I was on it whenever I had a mild flare and it worked well.

Colazal (generic name= balsalazide disodium) breaks down to mesalamine within the colon. I have never read that it affects peripheral neuropathy-- but in some patients 5-ASA meds can cause joint pain. The drug that is known to cause peripheral neuropathy with extended use is Flagyl (generic=metronidazole). / Old Hat (30 yrs with left-sided UC; presently in remission taking brandname Colazal)