I love raw manuka honey and use it with my VSL - honey is a good prebiotic.
Effect of Manuka honey and sulfasalazine in combination to promote antioxidant defense system in experimentally induced ulcerative colitis model in rats.
Medhi B, Prakash A, Avti PK, Saikia UN, Pandhi P, Khanduja KL.
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India.
[email protected]Abstract
Manuka honey (MH, 5g/kg) provided protection against trinitro-benzo-sulphonic acid induced colonic damage. Combination therapy (MH+sulfasalazine) also reduced colonic inflammation and all the biochemical parameters were significant compared to control and MH alone treated group. Combination therapy showed additive effect of the MH which restored lipid peroxidation and improvement of antioxidant parameters. Morphological and histological scores were significantly reduced in combination groups. In inflammatory model of colitis, oral administration of MH (5g/kg) and combination with sulfasalazine (360 mg/kg) with MH (5g/kg) significantly reduced the colonic inflammation. The results indicate the additive effect of Manuka honey with sulfasalazine in colitis.
Protective effect of natural honey against acetic acid-induced colitis in rats.
Mahgoub AA, el-Medany AH, Hagar HH, Sabah DM.
Department of Pathology, College of Medicine, King Saud University, Saudi Arabia.
Abstract
AIMS: The protective effects of natural honey against acetic acid-induced colitis were investigated in rats.
METHODS: Honey and glucose, fructose, sucrose, maltose mixture were administered, orally and rectally, daily for a period of 4 days. Induction of colitis was done on the third day using 3% acetic acid. Animals were killed on day 4 two hours after administration of the dose and colonic biopsies were taken for macroscopic scoring, histopathological and biochemical studies.
RESULTS: Honey dose-dependently afforded protection against acetic acid-induced colonic damage. There was almost 100% protection with the highest dose (5 g/kg) used while glucose, fructose, sucrose, maltose mixture produced no significant protective effect. Also, honey prevented the depletion of the antioxidant enzymes reduced glutathione and catalase and restored the lipid peroxide malondialdehyde towards normal levels.
CONCLUSIONS: Further studies are required to explore the active ingredients responsible for the antioxidant effect of honey and its therapeutic potential in humans.