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Coated Lecithin, N-acetyl Cysteine and the colon mucus layer

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Ulcerative Colitis
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Posted 9/3/2011 4:52 PM (GMT 0)
I am throwing this out there so someone who has more experience in understanding these scientific papers may be able to help out.
 
I've recently started taking the coated lecithin from klinipharm. I understand the lecithin is supposed to increase the protective hydrophobic surface in the colon.
 
However, I happened across something on PubMed which suggest that N-acetyl cysteine(NAC) which I take everyday may decrease mucosal hydrophobicity:
 
http://www.ncbi.nlm.nih.gov/pubmed/17693944
 
I tend to get a little lost reading these abstracts and would appreciate if anyone on here more experience than myself could help out.
 
Am I correct in assuming the use of N-acetyl cysteine(NAC) may be counterproductive to what taking coated Lecithin is trying to accomplish?
 
Thanks,
 
PF
Posted 9/3/2011 10:46 PM (GMT 0)
"Intestinal mucosal hydrophobicity showed a gradual increase from the duodenum to the end of the ileum and remained at high level in the cecum, colon, and rectum."

Ok well the upper intestine needs water to digest so it should not be absorbing water but instead adding it the food. This I think is why when dehydrated last summer and having a huge catered party on my deck eating all of that food pushed me further into dehydration resulting in a stroke and a week long trip to the ICU.

The large bowel however is primarily there to pull and reabsorb all that water back into to the body because it has done its job, water is reclaimed and at the same time waste needs to be reduced in volume. When this fails to happen we get the usual too many trips to the bathroom.

So that all checks out with my understanding - agrees with it.

"Both N-acetyl cysteine treatment and ischemia caused a dose-dependent decrease in mucosal hydrophobicity, which significantly correlated increased gut permeability. Mucosal hydrophobicity of the intestine can be reproducibly measured, and decreases in mucosal hydrophobicity closely correlate with increased gut permeability."

That is unexpected. Why decreased ability to absorb water results in greater gut permeability is a mystery to me. Throwing out my NAC regardless.
Posted 9/5/2011 5:57 PM (GMT 0)
pumpfast, how are you doing on the lecithin from klinipharm? do you think it is helping? i am taking that as well, and i think it is helping me some. just curious about other's experiences!
Posted 9/5/2011 6:10 PM (GMT 0)

kate22 said...
pumpfast, how are you doing on the lecithin from klinipharm? do you think it is helping? i am taking that as well, and i think it is helping me some. just curious about other's experiences!

 

Kate, i've just started on the lecithin from klinipharm 12 days ago... There may be some very slight improvement. I'm thinking it will take at least 3-4 weeks to notice anything significant. How long have you been on it?

Posted 9/6/2011 2:14 AM (GMT 0)
I've been on the lecithin for several months.  I was having a very difficult time getting off of prednisone.  I feel that the lecithin helped me finally get off the prednisone.  i really do think it's helping.  when you take so many different meds at one time,  it's so hard to tell what drug is actually doing the trick, but it seems like i was able to successfully taper the pred after talking the lecithin for a few weeks.  i hope it continues to help me, and i hope it will help you!  it is pricey stuff, but i think it's worth it.  keep us posted on your progress, i'd love to hear your results!
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