Anobody said...
It was my understanding that it was the carbon monoxide and not nicotine that cleared up the UC. So you still have problems with UC and are still smoking? I have been afraid to quit since I am unsure if it would clear up again if it were to come back. I guess I will just continue smoking since I don't have any UC problems at all.
A few studies, mostly older, did look at the CO, but most of the work has focused on nicotine. It has been shown to affect the immune system by binding to one of the chemical receptors and blocking (thus regulating) one of the interleukin messengers that signals between various parts of the immune system.
For this reason, the patch does help some people. Mostly people whose immune system had reconfigured over time to become accustomed to the presence of nicotine. (Less help for people who had never smoked before.)
Nicotine does cause metabolic damage in the body, and can harm the heart. It is after all a fatal poison in large doses. However, prednisone causes lots of damage too. I was not a smoker, and have no reason to believe that nicotine would help me. But if I had been a smoker until shortly before getting UC, or if I had some evidence that smoking mitigated my UC, I would try to find a level of trans-dermal nicotine that gave enough help to get off of Prednisone. If I was not prednisone dependent, I would be less interested. I think careful consideration needs to be made of the individual case.