I have used Xifaxan off label for years as a treatment for ulcerative colits-pancolitis. It has worked well for me in conjunction with Pentasa and I have been able to get insurance to cover it. I have also paid out of pocket and it is expensive. Cipro also worked well for me, but I unfortunately developed tendon problems which is a known side effect. And, I agree with Trojen that this disease has an as yet unidentified bacterial basis.