Can coffee work the same way as LDN

But many drugs have a similar half-life, like morphine for example. Is there any other basis to this theory?

Also, caffeine is a stimulant and some people find it makes their symptoms worse.

Regardless of the caffeine, the point I am trying to make is that Naltrexone binds to opoid receptors, and LDN binds at low dose for a short period of time,which then creates a rebound effect on endorphins, and receptor quantity. There are compounds in coffee such as chlorogenic acids that have this same binding ability as naltrexone or stronger, and perhaps this will work in the same way as naltrexone in this respect. The trick is to find the proper dose of instant coffee, right now trying 1/8 teaspoon of Folgers Decaff instant coffee,this of course could be way under or way over the proper dose.
Half life is important because you want the effect to stop after a few hours.
Tracking down the concentraion of these compounds in instant coffee is part of the the answer to the proper dose, then of course is the concentraion variable from brand to brand,batch to batch and or bean type plus many other variables.
What this boils down to is finding an alternative for LDN,THAT ANYONE CAN DO,from the above info in my first post this approach seems possible.  Will now have to re-read the literature and look for the concentraion of these compounds in instant coffee, then perhaps can make a more accurate guess at the amount of instant coffee necessary.

OK, one source I found states that instant coffee contains between 30-40 mg of chlorgenic acid/gram instant coffee. Very rough calculations until I can get to a good balance in a few weeks.

The bottle says 120 6 oz cups per 226 grams of coffee using a slightly rounded teaspoon.

226/120= about 1.88 grams of coffee/slighty rounded teaspoon, which equals about 56-75 mg

chlorgenic acid/slightly rounded teaspoon. So, if we split the difference that = say 65 mg chlorgenic acid.

Using this dose then to get down to 4 mg, 4/65=0.06.  0.06*1.88=0.11 grams of instant coffee,to provide the same 4mg of chlorgenic acid,which is the LDN common dose.

1.88/16=0.11 grams instant coffee/ 1/16 slightly rounded teaspoon, so you need about a half of and 1/8 teaspoon. Again very rough calculations,feel free to check my math.

Now I have to wonder if it is a good idea to block these receptors with large amounts of coffee during the day for years and years.

PS: I have not yet found the mg of chlorgenic acid/gram of instant decaff coffee,the source I am using seems to indicate that both kinds of instant coffee caff and decaff contain the same amount of chlorogenic acid.

http://www.realdose.com/wp-content/uploads/2011/07/Green-Coffee-Thom-E_J-Int-Med-Res-2007.pdf

Here is another reference indicating between 4-10% chlorgenic acid in instant coffee, which would equate

to between 40-100 mg/gram instant coffee.  So if the particular coffee has 100mg chlorgenic acid/gram coffee then we need to take about 40mg coffee,.04 grams which is less than we can measure easily. 

So if we dissolve 1 slightly rounded teaspoon coffee and bring it to 100 milliliters total volume then we have

1.88g/100 ml, or .0188g coffee/ml. So 0.04/0.0188=2.1ml of this mixture to get 40mg of coffee,giving us 4mg of chlorgenic acid.  This in the case of high chlorgenic acid in the coffee. So the actual dose of coffee is in the range of around 40-110 mg,for an average or high amount of chlorgenic acid in instant coffee.

If the coffee has a low amount of chlorgenic acid then need somewhat more coffee.

For now will stick to the 1/16 teaspoon dose.

By the way coffee enemas are dangerous.

 http://www.nature.com/ajg/journal/v105/n1/full/ajg2009505a.html

Old Mike

Post Edited (Old Mike) : 4/15/2012 1:03:18 PM (GMT-6)

I have to wonder if 1/16 teaspoon of instant coffee would irritate the gut, don't know.
Old Mike

Old Mike,

Facinating, and thank you for all the hard work and research you are putting into this.

I love the way your minds thinks - the push to solve the difficult puzzles (much like me).

So tell me how are you going to test this hypothesis? Will be trying it with coffee 1/16 of a teaspoon or the actual chlorgenic acid pills supplements?

I'm very curious as to see your results.

Please keep sharing your thoughts, your hypotheses, your puzzles with us, and thank you!

Mike,

Thank you for all the research you do.

Thanks to one of your earlier posts, I too am now taking L-Threonine, but in powdered form @ 2grams a day. How much are you taking of it?

But I am not taking it for UC reasons, but rather to help me rebuild my bones (which my bone density showed to be pretty bad thanks to prednisone), and I am also hoping it will help me with my terrible hair loss as well (that would make me pretty happy).

Here's some info I found interesting: "Threonine helps build strong bones and tooth enamel.Getting enough L-threonine can help alleviate anxiety and depression.

L-Threonine supports cardiovascular, liver, nervous system and immune system function. Because it assists in the production boosting neurotransmitters, L-threonine is crucial not just for general physical health but also for mental health. "

 

You said: Would like to switch to grass fed meat, wife thinks I am nuts, but at least she buys wild salmon like I tell her.

I think it's a great idea. If you want to find a local grass-fed animal products farm, you can go on www.eatwild.com

With regard to mayo made with olive oil, I believe I've seen it at Whole Foods.

But I found you a recipe that's supposed to be delicious and easy:

http://allrecipes.com/recipe/home-made-mayonnaise/

Ingredients

• 1 egg
• 1/2 teaspoon minced garlic
• 1 tablespoon lemon juice
• 1 teaspoon prepared yellow mustard
• 3/4 cup vegetable or olive oil
• salt and pepper to taste

Directions

1. Combine the egg, garlic, lemon juice and mustard in the container of a blender or food processor. Blend until smooth, then blend on low speed while pouring oil into the blender in a fine stream as the mixture emulsifies and thickens.

 

Mike,
So sorry about your son's colon.
Yes, I sure hope you can save your own.
Why not try the LDN? It's so cheap, and it's long term benefits are amazing, no?

Mike,

I hear you. A prepaid card would be a good way to go.

Yes, I think it would be great for you to try LDN.

I've heard lots of folks getting theirs from Mexico or India as Naltrexone (@ 75mg tablets) and they dissolve 1 tablet in a certain quantity of water (giving it time to dissolve fully and have all the binders pulled out of it), and siphon out with a syringe a certain amount which would equal a dosage of 4.5mg.

Please keep us apprised of how and when you'll be doing this.

Alldaychemist.com is who I ordered tablets from.  I'm on the cream right now, but am breaking out in a rash in the areas I apply it to.

 

blueclassring,

Alldaychemist.com is who I ordered tablets from. I'm on the cream right now, but am breaking out in a rash in the areas I apply it to.

Did you find out what the formula for dilution is with the tablets? Which mg tablets did you get?

Can you give me the formula for dilution, if you know it please? I need to give the info to someone who cannot get a prescription for it.

With regard to the breaking out of the cream, please do not be alarmed. It seems some people, myself included, sometimes develop an allergy to the oil base in the transdermal cream at the application site. I too developed an eczema type rash at the local site where I would apply the cream (with Emu Oil base). I stopped using it. They made me another transdermal cream (with Safflower Oil), and a few weeks after that, I became allergic to that as well. I've been told that it is not uncommon a reaction in immune compromised people (like us with UC, and autistic kids too), and that there are some patients who are actually on their 4th oil base in the cream.

After much research, I finally found a different way. I now get sublingual Troches from Skip's Pharmacy, which they make for me (you can pick a flavor to cover up the LDN taste, I chose butterscotch). You have to put the Troche under your tongue, and it takes approx. 15 min, until it dissolves completely. I've been doing this for about 3 months now and it's been very successful.

Let me know if I can answer any other questions for you.

As a pharmacist, I may have to open a compounding pharmacy so I can help some people too.

Also, in the future you may want to ask Skip if he can make sublingual drops. That maybe even more convenient for you, but the butterscotch troches are good as well!