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6mp feeling sick to my stomach

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Ulcerative Colitis
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Posted 8/8/2012 2:37 AM (GMT 0)
I had my UC in remission until this past April. I had a horrible flare, I think due to stress. I was put on pred which initially improved things, but as I tapered off my symptoms got worse. I was put on 6-MP along with a small doses of pred for the past 6 weeks. One symptom I absolutely hate is how sick I feel when I go to the bathroom. Every time I pass a bowel movement I feel sick to my stomach. It is so exhausting. I have to breath deeply and tell myself everything is going to be ok EVERY time I go to the bath room. This sick to my stomach and nauseous feeling has been going on since I've been put on 6-MP. Some days aren't so bad. I'm curious to wonder if anyone else feels this way when on 6-mp. Some symptoms are improving slightly, but I am very far from 100%. How long does it take for the 6-MP to start kicking in? Other than that I just got married last weekend and am hoping that things will start improving soon. The wedding was amazing but I had so much stress related to preparing for the big day. I have also been using colocort enemas, which I believe have been helping. Any advice would be great. :)
Posted 8/8/2012 3:05 AM (GMT 0)
6 mp is supposed to take a couple months to fully help.

I was on 6mp for 5 or 6 years, and now I am on Imuran (which is the same thing once metabolized). I do feel nauseated more days than not. I contribute a feeling of fatigue and a "slightly poisoned" feeling to the drug. I have never felt worse when having a bm.

I'm not certain what colocort enemas are (steroid enemas?). I have a terrible feeling when taking Rowasa enemas though... as if I have the flu bad. It's always hard to tell with meds and side effects, except by continued trial and error.

If you have any more questions about 6mp, please post them here and I'll see if I can answer them.

Congrats on the wedding! I hope one day to be lucky enough to find someone special to be married to. Be thankful you have that! :)
Posted 8/8/2012 11:41 AM (GMT 0)
After a remission of about 1.5 years, the medication I was on (Lialda) stopped working and I flared. I've been on Mercaptopurine (6MP) and Prednisone (which is bad for me in that while it helps with colitis symptom reduction, it makes my blood sugar get dangerously high as I'm a diabetic). I too get a "poisoned" feeling off the 6MP though I've only been on it for about 2 weeks. It's a chemotherapy drug so this is to be expected to some degree. I made the mistake of mentioning the word 'cancer" to my mom...she freaked and is convinced my doctor is secretly treating me for a cancer he does not want to tell me about. You know...secret cancers, UFOs,  Sasquatch...it's all good. While my colitis is improving, my diabetes is going down the toilet (no UC pun intended). What can you do, eh? Just stimulate the economy via my seemingly endless presence at the pharmacy and doctor's offices.

Some of my recent side effects of these meds: high blood sugar levels, extreme fatigue, abdomial pains of various sorts, bloating, muscle/joint aches, irritability and the ever-popular general feeling of malaise.

Posted 8/9/2012 1:56 AM (GMT 0)
Thank you both for your responses. I think your positive attitudes help more than anything.
@ Thoreau - so did you feel like through out all those years on 6-MP? I guess I'm hoping as things improve, the sick feeling will go away? And thanks for the congrats! It is so important that we really appreciate what we have! I hate that my UC will bring me down enough sometimes to see the amazing things in front of me.

@Mammatus - Sorry to hear about the juggling you have to do between the UC and diabetes. Hopefully you can find a balance. Let me know how you progress on the 6-MP.

The most important thing for all of us is to just have a positive attitude. I guess I need to be patient. I am going to try some acupuncture this week. I am also looking into the SCD. I've even been suggested to try nicotine mints, but I'm going to wait on the nicotine idea.
Posted 8/9/2012 3:05 AM (GMT 0)
As I have heard, nicotine will reduce the risk of having uc. on the contrary, I don't beleive it will help cure uc. keep on good food and mood, regular medicine. Good luck.
Posted 8/27/2012 12:53 AM (GMT 0)
I would love to hear how everyone does on the 6mp as well. I have had UC for 10+ years, basically flare free until 6 mo. ago. I was on the asa med, but apparently they stopped working. I was in the hospital for 5 days and sent home on prednisone and started the 6mp. Just last week.
I am concerned that when I start to taper off the prednisone that it wont wont work!
Has anyone had gas pains yet? So hard to figure if this new pain I am feeling under my right breast is gas or something more urgent, like pancrease or liver issue.
This disease is so complicated, so frustrating!!
When did you sll, or have you had a regular stiff bm after starting your pred. 6mp? Any help appreciated, I am so tired of the guessing. I am having blood drawn every week, but just started this regime last week, so no results yet!
Posted 8/28/2012 11:19 AM (GMT 0)
I've been on 6MP for about 6 years now.
I felt rotton for a good week and a half when I started taking it - or upped the dose. It does wear off and you should feel normal. I also never had any increase in colds or infections while on it.
It helped me a lot and reduced considerably the frequency of flares.

I'm now coming to the end of my road as I'm seeing a surgeon next week - but it worked well for me for a long time.

Good luck!
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