Sodium Butyrate Eaters.. how's it going?

I started it last Wednesday and it seems to possibly be helping. Hard to say because at the exact same time, I started cortisone enemas, a robust probiotic, cut out dairy and sugar, and am eating low fodmap foods in a desperate attempt to get out of this flare. If I didn't have my two little girls to chase after everday I might have been able to add each change slowly to see what made the biggest difference, but alas, I don't have that kind of time. I definitely don't think the sodium butyrate is hurting, which is enough for me to keep doing it. Thank you soooo much for the referral (and all your advice)! What I found interesting is that sometimes during the day while eating a low fodmap diet, I would still have some urgency and very loose stools... Then I noticed yesterday evening that the chicken breast deli meat that I was using on my corn tortillas (corn tortillas suck) contains carrageenan. Gah! So I switched to a ham deli meat that is carrageenan free and low and behold, I have yet to use the bathroom today and have since eaten three different meals since dropping the chicken. I wish it wasn't in practically EVERYTHING! I don't want my girls developing IBD, so I will probably go on a binge and throw away everything containing this IBD-causing toxin. Whether or not it was contributing to my flare, it certainly wasn't helping things.

Meridith, carnegeenan was so hard on my stomach when I was healing. I had to use the almond breeze milk in a tetrapak because it was the only thing that didnt have it. Its ridiculous that they put it in so many things! Lunch meat! Good grief. I only would eat boars head at that point as it seemed the least full of potential triggers. I now drink products that contain it with no apparent problem but I steer clear for the most part.

Its so hard to do this with children. I have two little girls too. But I have a tremendous amount of help from my husband who works from home too. Good luck, I really hope you keep improving.


protocoltek, hopefully if you can just keep your stool softer then you can heal the cause of the blood and mucus more easily. Glad the mag citrate and chia seem to atleast be softening the stools a bit. I think it's smart to use the canasa to get over any healing bumps ;) Thanks for your feedback.

Yesterday my doc told me that butyrate + berberine is a powerhouse for candida killing. We added berberine because Im trying to address a saprophytic fungi overgrowth. So, hopefully this next wave of additions wont mess with the good thing Ive had going this last couple months. I literally have no issues UC wise anymore. Infact, Ive gained 13 lbs since the beginning of april. That's how much Ive been eating. LOL, doc told me the butyrate would make me lose weight and since I had lost 70+lbs in the last 2 years he wanted to keep an eye on weight loss. Obviously not an issue.

Maybe we can get a healing well discount ;)

I have been taking BodyBio Sodium Butyrate 600mg caps X 2 or 3 per day. In the beginning, I noticed some immediate improvement. Over time the pain has migrated down my colon (I interpret this to mean things are healing) and now it's localized to the very end. I still have some B, M and urgency, but because I started feeling better I avoided a cycle of TheDreadedPred! I'm also on Rowasa nightly, which is certainly helping as well.

Initially I had some joint pain in my fingers, which I now attribute to the Uceris (since it went away when I abandoned the drug). I would still like to talk to my MD about Sodium Butyrate, but honestly I think it was the best alternative therapy I have tried (the Squatty Potty is #2, no pun intended) and I hope to keep using it!

Many thanks to those brave folks who tried it and shared the info.

Little buddy, the end is the hardest heal. You should be our guinea pig and try doing small butyrate retention enemas or formulate it yourself into a coconut oil suppository ;). Nobody is even taking it the way it has been most studied..

www.scbt.com/datasheet-202341-sodium-butyrate.html
Sodium Butyrate has been reported to cause hyperacetylation of histones due to its role as an HDAC (histone deacetylase) inhibitor. This compound has been shown to cause induction of differentiation and gene expression and also prevent cell proliferation. Mechanistic studies suggest that the action of Sodium Butyrate is often mediated through Sp1/Sp3-associated HDAC activity which leads to transcriptional activation of the p21 gene. Additionally this agent demonstrates the ability to downregulate numerous genes associated with cytokine signaling, specifically, the IFN-γ (interferon γ) pathway.

Sodium butyrate really is a wonder.

It says there that it's Dissolveable in water,(and DMSO..which is an interesting idea for topical delivery) so I'd just try gently warming the coconut oil, maybe 2tbsp each suppository... it would be easiest to make multiple ones at a time.. Warm it to no higher then 100, just till liquid...then mix in the contents of a capsule of the butyrate..if it dissolves, try 2 caps. (start at 2.. I bet you could get to 4.) then pop the bowl in the fridge.. Use a glass or Pyrex bowl. When the coconut oil starts getting solid, spoon it to the middle of some wax paper and make it into a cylinder, twisting off the ends. Freeze and use from freezer.

I'd start with 1. Try 2 pills for each sup.. 600mg per pill. To refine the process, you may have to dissolve the butyrate in a tiny amount of water then make an emulsion. It would be a lot easier if it just dissolves in the oil.

Think of making a single one like a jolly rancher, lol. Make a longer one like a thin cigar if you do 4 at a time . After it is solid, unwrap and and cut into even sized portions.

Ive made coconut oil probiotic suppositories this way before and they didn't stick to the wax paper.

Got it-thanks, Pathogen !

Little Buddy said...
I forgot to mention that I also started the Key-E Suppositories during the day (as adjunct to Rowasa at night and instead of dropping $ on Canasa). I can't say they're helping much - maybe they lubricate the tissues, but since I use them in the AM I almost always end up expelling them during the course of the day. I'm thinking of asking for steroid supp's at my next Dr. Appt, but will be interested to hear how the Coconut Oil + SB homemade experiment goes.

I am eating some Resistant starches - cold rice, rice pudding, tapioca, cold potatoes, cold pasta. Have basically stayed away from beans. I was thinking about the problem of having too fast Whole Gut Transit Time (I think mine is less than 24 hours based on foods I've seen), and how RS needs to ferment in the large intestine to deliver Sodium Butyrate. I remember reading here on HW that some people use marshmallows to slow their system down when the D is bad. I might put myself on a daily dose to see if that would allow the Resistant Starches to do their work. Thoughts? Or I could try one of those IBS drugs, but I am so sick of pills!

Psyllium will help add bulk and slow transit.

Psyllium husk (Metamucil), Citrucel, and later Benefiber is what (I believe) started this flare in the first place. Started these in January in sequence over a month until I descended into chaos. Turns out I can't handle much fiber if I'm torn up at all. Other ideas?

Little buddy, do you have any form to your fast transiting stool? Is it orangish in color or dark brown?

I went back and noticed you said 24 hours. I sdont know that is really a fast transit time, actually. Supposedly our digestive tract would produce a bowel movement for every large meal and it's optimal to transit in 24 hours, I think the range is 14-24 hours.