C_G_K said...
OK, I'm jumping into this thread late, so this may have already been discussed, but butyric acid in high concentrations being beneficial to the colon is questionable.
See here for example:
http://gut.bmj.com/content/52/1/79.abstract
U.C. researcher said...
Twenty four hours after mice were given enemas containing either butyric acid or F varium culture supernatants, colonic ulcers with crypt abscesses, inflammatory cell infiltration, and apoptotic changes were observed.
C_G_K said...
Enemas containing butyric acid can be used to trigger U.C. in mice.
I'm sticking to the husk for now.
I'd just like to add my two cents that I think drawing conclusions from this mice study is very incorrect (and it is likely being misunderstood). Butyrate enemas (another term for butyric acid) are a known potential treatment for colitis. See for example:
"Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis"
https://www.ncbi.nlm.nih.gov/pubmed/1612357"Butyrate inhibits NF-kappaB activation in lamina propria macrophages of patients with ulcerative colitis"
https://www.ncbi.nlm.nih.gov/pubmed/11989838"The role of butyrate on colonic function"
https://www.ncbi.nlm.nih.gov/pubmed/17973645"Butyrate modulates oxidative stress in the colonic mucosa of healthy humans"
https://www.ncbi.nlm.nih.gov/pubmed/19108937It is because of the known potential benefit of butyrate enemas for colitis that the researchers did the study on psyllium seed powder in the first place.
Further, it's not stated in the abstract of the study about
psyllium seed powder (
https://www.ncbi.nlm.nih.gov/pubmed/10022641), but if you have access to the whole study, you can see that they used pysllium seed powder (not psyllium husks). So I think psyllium husks may be fine in general, but they have not been demonstrated to benefit colitis and people are failing to follow the insight discovered in the study about
psyllium if they are not using psyllium seed powder. I think this is a very common mistake people with colitis make, because they've heard about
psyllium via word of mouth, but not looked at what was actualy done in the study (as the orginal post in this thread tries to clarify).
My experience, after I discovered the study on psyllium seed powder, was night and day. After fourteen years of colitis with several flares a year and the rate of flares increasing, I went into complete remission for five years and stopped taking any medications. (I had been taking twelve Asacol a day for those fourteen years and used Mesalamine enemas to get out of flares, but the Asacol seemed to maintain remission for less and less time.) I only had one flare after five years, because I got a bad samonella infection and my doctor thinks it triggered the colitis overactive immune response (I used Mesalamine enemas again to get out of that flare). I take 1/8 of a cup of psyllium, three times a day, mixed into a large glass of water.
I'm also mindful of my diet and use probiotics, but it was really the psyllium seed powder (not husks) that made the difference. I take no pharmaceutical medications anymore.
Post Edited (gg555) : 7/25/2021 7:45:48 PM (GMT-6)