Hopefully they can put a few things together that max benefit and minimize side effects. Some of the risks seem similar to biologics already offered for UC:
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0010674/?report=details said...
Warnings
Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
Make sure your doctor knows if you are breastfeeding or if you have kidney disease, liver disease, anemia, bleeding problems, edema (fluid retention), heart disease, congestive heart failure, lung disease, stomach or bowel problems, or an underactive thyroid.
Check with your doctor immediately if you have swelling or rapid weight, chest pain or uneven heartbeat, trouble breathing, or extreme tiredness or weakness. These may be symptoms of heart problems or your body retaining too much water.
Check with your doctor right away if you have stomach pain, pale stools or dark urine, loss of appetite, or yellow eyes or skin. These could be symptoms of a serious liver problem.
Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering or peeling skin, a rash, sores, or fever or chills.
This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
This medicine may cause slow growth in children. The doctor will need to keep track of your child's height and weight to make sure that your child is growing properly.
Call your doctor right away if you have less urine than normal, swelling in your feet or legs, or stomach, joint, or back pain. These may be symptoms of a serious reaction called tumor lysis syndrome.
This medicine may make you dizzy or drowsy or cause blurry vision. Do not drive, use machines, or do anything that could be dangerous until you know how this medicine affects you.
Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.