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Do Uc always but always starts in rectum

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Posted 9/9/2014 5:11 PM (GMT 0)
Just one more thing if UC always starts in rectum that means that checmical imbalance unkown bacteria or something else is going up not like chrohns where it is not connected here is connected. I have read a theory that is about autoimmune system that want turn off. Lets call it occam razor. If it starts at the entrance it means that something got in from it have found a great place to live going up till the small intestine.
From this point of view it is likely to be bacteria.
Sorry for two threads but it is somehow easy to explain it this way.
Posted 9/9/2014 5:31 PM (GMT 0)
Yes uc always starts in the rectum, by the very definition of the disease. Otherwise it is crohn's.

I cannot speak in regard to the cause of uc; it is unknown. However oldmike and canadamark often talk about things such as this so perhaps they or others will answer that part if your question.
Posted 9/9/2014 8:14 PM (GMT 0)
Not sure what the rest of the post was talking about, but yes, as iPoop said, it always starts at the rectum.
Posted 9/9/2014 9:00 PM (GMT 0)
UC is more than likely autoimmune and not caused by a bacteria. It may be your body's immune over-reaction to a bacteria you already have but you are probably barking up the wrong tree by thinking he caught some kind of bacteria which caused his UC.
Posted 9/9/2014 11:16 PM (GMT 0)
Another way to explain this is that.
In the rectum there is the highest mechanical force,the highest bacterial load,stool stasis, increase in luminal toxins, depletion of phosphotydal choline,increase in bacterial protease,probably a decrease in alkaline phosphatase,increase in bacterial protease,overwhelmed antiprotease in the gut, and other reasons of which I cant think of right now.
Old Mike


One of my favorite papers

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1434463/pdf/gut00225-0008.pdf


and I love this one,he pulls no punches

http://www.ncbi.nlm.nih.gov/pubmed/10465666



Post Edited (Old Mike) : 9/10/2014 4:24:41 AM (GMT-6)

Posted 9/10/2014 10:11 AM (GMT 0)
I have inflammation in rectum then a part of healthy colon and then part with UC in sigmoid. After rectoscopy I saw „Crohn‘s in suspect“ on a list so I was surprised I was diagnosed with UC. But UC was confirmed with biopsy so I never asked how this possible and why it‘s not Crohn‘s.
Posted 9/10/2014 11:14 PM (GMT 0)
The oral mesalamines don't get down to the rectum. If I skip a two days of my mesalamine enemas, I start with constipation then I have poop accidents. So I can't slack off. UC does start in the rectum. My orals must be doing their job because I have pancolitis.
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