nausea & 6MP...???

I took 6mp for about six or so years. It's been long enough that it's hard to recall, but in general I felt a bit fatigued most of the time while on it. I remember being given nausea drugs around that time as well, so it could be that I experienced it. In general the drug IS affecting your body and you do feel its effects to some degree... but I never considered it as having extreme side-effects. I was on a dosage around 100 mg I believe... and I weighed 150-160 lbs at the time I think.

I had some mild nausea when I started taking 6mp but my body got used to the med at around the 3 month mark and my side effects went away.

I was on 6MP for roughly 8 months before tests revealed it wasn't working for me. I started at 50mg/day and that didn't make me nauseous, just changed the way food tasted in very subtle ways. Once I started on 100mg/day then 125mg/day I got nausea to the point where I was skipping meals and eating very "safe" foods. The nausea was most severe when I increased my dose and would gradually settle into a steady-state once I got used to it.

I'm now on 25mg/day of 6MP to help with the Entyvio infusions with no side-effects.

Thanks for all your responses.

Thoreau, do you remember what anti nausea drug you were given? Do you recall why you stopped the 6MP?
DB, you are right- 50 mg is low but it is based on my weight. I am also an intermediate metabolizer of 6MP so I don't break it down readily. I get frequent blood tests to make sure it doesn't become toxic to me.
ipoop & Red thanks for your input. I will be seeing my gastro Dr. next week & will speak with him about my nausea.

Stewiecat you are so right. Usually I would normally have an appetite & enjoy my food. But this nausea kills my appetite. I am also on Entyvio like you.

LOL Blksteeda. You made me chuckle about your appetite & the battle between 6MP & pred.

The consensus of all responses seems to say to me that hopefully this will get better with time. I will stay the course.

I have been on 6MP for over a year now. I never experienced any nausea, but I was getting fatigued and I did attribute that to the 6MP. Thankfully, the fatigue only lasted 3-6 months (can't remember when it went away) and has not been an issue at all since it faded.
I have heard of people experiencing nausea changing the time they take their dosage and having some success with that.

twingirl812 said...
Thoreau, do you remember what anti nausea drug you were given? Do you recall why you stopped the 6MP?

I believe I was given Zofran. I wasn't given enough to take it daily, just enough for times when it was bad I guess. I did not end up using a lot of it.

I stopped 6mp because I got to a point where I was not in full remission, and according to the labs they drew raising the dosage would endanger my liver.

I actually like 6mp/Imuran as an option for people that don't do well on mesalamines. I remember a bit of a sick feeling and fatigue from the drug that did not ever go away... BUT, I am uber sensitive to ANY medicine. Way more so than most people. I personally have experienced way worse things because of Remicade I believe, though most do fine on it as well.

I am in remission on no medication currently (stopped due to severe pain I associate with Remicade). I am fully considering trying Imuran or 6mp.

Do keep in mind that 6mp and Imuran are the same thing, but are metabolised differently... so you could ask around or research and see if one of them was more prone to causing nausea. I did hear about a shortage of Imuran though; not sure if that is still the case or not now... was 3-6 months ago.

You will get to a good spot with this.