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Curcumin in Combination With 5-aminosalycilate Induces Remission in Patients with Mild to Moderate U

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Ulcerative Colitis
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Posted 3/1/2015 1:16 PM (GMT 0)
I am sure many have taken curcumin, as have I , don't think I took 2.5 grams/day whichI found in my 2012 thread. If it worked for me would still be on it.
This is hot off the press.

But at any rate here is a human trial, with 5 asa, seemed to work reasonably well.
Since it helped the non 5asa responders who were getting both oral and topical therapy.

Old Mike

http://www.ncbi.nlm.nih.gov/pubmed/25724700
Posted 3/1/2015 1:25 PM (GMT 0)
Yes, that is why curcumin is included in my signature. It really works. I only take it as needed after eating something bad and want to get back into remission before my symptoms morph into a full-blown flare. But since it is so effective maybe I should take it every day.
Posted 3/1/2015 4:16 PM (GMT 0)
too bad asacol gives me the poo's cant do any sulfur drugs, however I wonder since reading the Briggs protocol if I can take it once I get everything under control.
Posted 3/1/2015 4:32 PM (GMT 0)
May be a dumb question, but where does one get curcumin? At a grocery store or does it have to be a health food store
Posted 3/1/2015 4:34 PM (GMT 0)
I took 4x-10x the daily dose of curcumins for about a month, from a variety of Amazon.com top rated brands and did not experience any significant benefits. It was expensive and did not seem to have any long or short term effects.
Posted 3/1/2015 4:37 PM (GMT 0)
Healthfood store, amazon.

Like I said have tried in the past,no effect on me but was not taking 3 grams/day.

But from this trial of human non 5asa responders, it looks interesting.

Old Mike

Posted 3/1/2015 4:41 PM (GMT 0)
Were there any details about how/when it was taken? All at once? Split into multiple doses?
I've been taking 1.5g/day at dinner. Thought it was working, but have a minor flare again.
Posted 3/1/2015 4:47 PM (GMT 0)
I want to try this, I was taking tumeric but half assed and sporadic. I need to find a good regime and get my act together!!!

Really stick to something. Let's find a good brand and dosage?
Posted 3/1/2015 4:49 PM (GMT 0)
FYI - just sent an email to 3 authors from Sheba Medical Center asking for dosage details.
I'll report back with anything I hear.
Posted 3/1/2015 4:55 PM (GMT 0)
That's great Eph!
Posted 3/1/2015 4:57 PM (GMT 0)
Just eating turmeric as a spice when cooking won't do the job, only contains about 3% curcumin.

Fight UC: That was my experience but don't think I took as much as you have.
Old Mike
http://www.ncbi.nlm.nih.gov/pubmed/17044766


Seems that I took 2500mg a day back in 2012, also some cautions on bleeding and gall bladder and

other stuff. My old thread.

https://www.healingwell.com/community/default.aspx?f=38&m=2526987


bioprene might work, but not actually sure you want to increase absorption might want to keep it

In the colon.

Post Edited (Old Mike) : 3/1/2015 10:28:43 AM (GMT-7)

Posted 3/1/2015 5:07 PM (GMT 0)
Mike, you buy into this claim about Bioperene as an additive to increase absorption? Seems like there are a lot of claims about bioavailability.
Posted 3/1/2015 11:56 PM (GMT 0)
Most people who claim success with Curcumin take at least 3 grams per day or more, sometimes a lot more. I took 1.5 grams along with 1.5 grams of Boswellia but it did very little for me. I may have to think about trying 3 grams of just Curcumin and see if that does anything but right now I'm doing pretty well.
Posted 3/2/2015 12:35 AM (GMT 0)
Great news! I'm taking 1g/day Curcumin C3 which contains Bioperine. Claims to be 2000% more bio-available. Mike, I don't think it has to hit the colon to be effective, it just needs to be absorbed by the body into the bloodstream. Not sure. I do think with the more bio-available types one wouldn't have to take 3 gs. Viva Labs Curcumin C3 is available at Amazon and it's fairly inexpensive. Anyway highly recommended by my ND but my MD just smiled and nodded.
Posted 3/2/2015 1:05 AM (GMT 0)
I guess it depends where you want it.

According to this eating with food will put more into the colon, as opposed to plasma.

I might guess if you want both eat some with food and some without.

OM

http://www.ncbi.nlm.nih.gov/pubmed/11350917

Posted 3/2/2015 1:33 AM (GMT 0)
Thanks OM. I have inflammatory issues throughout my body. Will make a point of taking it with food henceforth to concentrate on the colon.
Posted 3/2/2015 5:39 AM (GMT 0)
Love seeing this research since curcumin is my maintenance drug - 3 g per day while in remission. If I could take 5ASAs, I'd probably do both.

But maybe it's the curcumin that's maintaining remission, not the 5ASA! I wish they'd included a group that took a placebo 5ASA with real curcumin.

What I take is in my signature. I always take it with food that includes some fat to help absorption.

I've kept detailed notes on my daily condition for the past three years and based on those, there's no doubt in my mind that the curcumin is what's keeping me healthy.

The only side effects I've had at doses as high as 6 grams per day are 1) yellow on the toilet paper after I poop, and 2) the occasional burp that produces yellow fog. The first time freaked me out until I realized the capsule must not have made it down far enough to not be burped up.
Posted 3/2/2015 6:19 AM (GMT 0)
I picked up Theracurcumin a few days ago and they claim superior absorption too of course.

Cool video of it dispersing in water.

/www.youtube.com/watch?v=Wwg9vPUV9lg

www.amazon.com/Natural-Factors-Curcuminrich-Turmeric-Extract/dp/B00GHC2FL2/ref=sr_1_2?ie=UTF8&qid=1425277273&sr=8-2&keywords=theracurcumin

doctormurray said...

This all-natural preparation reduces the particle size of curcumin, while dramatically increasing its solubility. The average particle size of typical curcumin is 22.75 μm. In Theracurmin, the particle size has been reduced to 0.19 to 0.3 μm—a reduction of over 100 times. This reduced particle size curcumin is then mixed with natural emulsifiers to suspend it in a highly bioavailable mixture that is then dried. The result of all of this technology is a dramatic increase in the absorption of curcumin as compared to all other commercial forms that have been tested, including other enhanced forms of curcumin.

doctormurray.com/sponsors/theracurmin/

Post Edited (aguywithuc) : 3/1/2015 11:25:08 PM (GMT-7)

Posted 3/2/2015 12:15 PM (GMT 0)
Kiptyn: It might be the wellbutrin that is keeping you in remission.
Check out the Briggs threads.
Old Mike
Posted 3/2/2015 1:51 PM (GMT 0)
I want to start taking 3g/day, but I don't see any that contain Bioperine *and* come in a dosage of at least 750mg/capsule that aren't VERY expensive!

Can anyone share best deals they have found to get to 3g/day with Bioperine?

Thanks!
Posted 3/2/2015 2:13 PM (GMT 0)
But maybe it's the curcumin that's maintaining remission, not the 5ASA! I wish they'd included a group that took a placebo 5ASA with real curcumin.

I would be interested in this as well, but I doubt it will happen.

Turmeric has been used in Indian cuisine as a prophylactic agent for millennia. It's suspected the low rate of IBD, Alzheimers and cancer are due to the curcumin, among the other spices used in cooking. It is also a vital part of Ayurvedic medicine. Every healing protocol needs to incorporate it as an adjunct treatment due to the thousands of publications on it.

As for me, I cook with turmeric but I still believe I am getting the benefit of it.
Posted 3/2/2015 4:32 PM (GMT 0)
Received a response from one of the authors of the study, Nir Salomon:

"Better to split to 2 doses, take before a meal."
Posted 3/2/2015 6:12 PM (GMT 0)
So does it need to be coated in something special to reach the colon to be effective? Or can taking any old supplement work? I figure this might be worth a try.
Posted 3/3/2015 4:02 AM (GMT 0)
Old Mike, it's true that the Wellbutrin could be keeping me healthy but I have several reasons to believe the curcumin is doing something.

1) during my seven month long recovery from my first -and only - severe flare, I wasn't able to get below 20 mg of Pred until I started the 3 mg of curcumin. I have detailed notes on this and the timing is within days. And I was taking Wellbutrin before the flare, during it, and while I was getting off Pred.

2) I had a bad flare in the fall of 2013. It started while I was taking Wellbutrin and continued while I kept taking it. I was on Pred, Uceris, and hydrocortisone enemas, carefully tracking progress. The day I started to get better was the day I started taking 6 mg of curcumin. Everything else had been the same for weeks with minimal improvement until the increased dose of curcumin. Of course, it may have been everything else finally starting to work but I don't believe it. I continued to get better even after quitting the Uceris and tapering the Pred. It took me only 7 weeks to go from 60 mg of oral Pred to zero. I was off the enemas a few weeks after that.

There have been six month-long periods over the past 25 (!!) years where I stopped the Wellbutrin and tried other antidepressants and didn't flare.

I was also off Wellbutrin for two years while pregnant and breast feeding. The rule of thumb For UC during pregnancy is 1/3 of UC patients get worse, 1/3 get better, and 1/3 stay stable. I was in remission when I got pregnant and was lucky to stay that way I stay
but if Wellbutrin was the reason I was in remission, I'd think I would have been one of the patients who got worse. Especially in the year after my son was born.

I feel very lucky that I happened to start taking Wellbutrin when I was 22, long before my UC showed up, and I'll do everything I can to stay on it but I'm convinced it's not the only thing doing the job. Along with evidence from the peer-reviewed studies on curcumin, even Dr. Briggs says curcumin has anti-TNF capabilities.

Thanks for posting the research and your insights. They're very helpful and much appreciated.
Posted 3/4/2015 3:58 AM (GMT 0)
I am wondering if anyone has used Jini Patel Thompson's book Listen to your gut for advice for UC or Crones
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