LDN Effectiveness and Genetics

I'm still trying to find the original study, but I just read this on a couple sites:

"People with the G allele for OPRM1 rs1799971 have a better outcome when using naltrexone than people with the A allele. This study was done on naltrexone and not the low dose. Here is what 23andme states:

As part of a much larger study, researchers studied the effect of genetics on naltrexone effectiveness in treating alcohol dependence by comparing 146 patients who received naltrexone to 161 who received a placebo. All 307 patients also received counseling about adherence to their medication plans. The researchers found that SNP rs1799971 in the OPRM1 gene influenced the likelihood that a person taking naltrexone would have a “good clinical outcome,” which was defined by either abstinence or moderate drinking without problems. Patients with a G at one or both copies of rs1799971were more than five times as likely to have a good clinical outcome compared to those with the AA genotype. "

My results in 23andme show that I am AA. So, I am considering dropping LDN from my regimen, especially given how my dreams have become much more pronounced lately.

Food for thought.

I'll publish the study if/when I find it.

You are probably talking about www.ncbi.nlm.nih.gov/pubmed/19053977 and/or www.ncbi.nlm.nih.gov/pubmed/18250251
Did you investigate how this one works in conjunction with IBD pathophysiology?

Honestly have no idea what any of that means or how it relates to me specifically, but I have been on LDN now for about 7 months and it has helped me for sure. Not so much directly related to UC or my colon but I for years would wake up and have to vomit bile most mornings - maybe 5 out of 7 days a week. For years I tried all sorts of different things to try and stop it, LDN stopped it 2 weeks in and have not had that issue since. Haven't experienced any dreams though - kind of wish I would it would be nice to dream and remember it once in awhile.