This has been posted, but has anyone actually tried it?

I posted this in Old Mike's thread, but I don't think anyone's going to read through a 300 post thread before addressing my question at the very end. I hope it's not a problem to turn the question into its own thread.

Anyway, to briefly summarize, the thread refers to something called the Radical Induction Theory for UC. Here is a link to the theory:
www.google.com/patents/US8476233

The gist of it:
- UC has multiple causes or triggers (genetics, diet, pathogens, medications, etc) that, when they come together in a perfect storm, lead the body to produce too much hydrogen peroxide in the colon. This is called the 'induction phase' of UC
- The H2O2 ends up "attacking" the colonic cell wall, causing fecal bacteria to leak into what is normally sterile territory. This triggers a normal immune response.
- However, to kill the invading bacteria, the immune system responds with additional H2O2 production. Thus the perpetual UC cycle is established. This is called the 'propagation phase.'

So, to successfully stop the cycle and deliver full remission, the author proposes:
A daily enema consisting of: 5-asa, budesonide, sodium butyrate, and cromolyn sodium
And orally taking R-dihydrolipoic acid

I'm just wondering if anyone here has tried this treatment. Obviously we all know about 5-asa and steroids. Butyrate is on the 'alternative' side but I wouldn't call it controversial. Lipoic acid is an over-the-counter supplement. I know the least about cromolyn sodium, but a quick google search didn't turn up anything cautious or dangerous. So it seems each of these components are normal and nothing extreme, but I was particularly curious if anyone tried this treatment together, at the same time, in the manner described by Dr. Pravda. Anyone?

Post Edited By Moderator (Judy2) : 8/6/2015 6:19:17 AM (GMT-6)

If I'm understanding the patent correctly, then I think it addresses your points:

1. UC's emergence in the last 100 years
- The patent discusses the importance of having fiber in your diet in order to produce butyrate. Thus, I think the author would argue that the emerging "western diet," has something to do with UC. Burgers and fries means no fruits, vegetables, or fiber.

2. Initiation in the rectum
- Most amusing part from the patent: "The greatest risk factor for ulcerative colitis is the presence of a rectum."

3. Continuous inflammation
- I would just read up on the 'propagation' the author talks about. His theory supports the idea of continuous instead of patchy inflammation.

Also, I don't think the unique part of this theory is the suggestion that oxidative stress contributes to UC. Lots of papers talk about that link. I think the only novel argument here is that UC is a two phase disease. Phase 1 being the induction phase where no symptoms are present, then phase 2 being the propagation phase where symptoms show up.

aguywithuc said...
no joy from R-dihydrolipoic acid orally.

Meaning it didn't help, or it made things worse?

All you have to look at is his clinical trial results.

Yes a very small trial, no question.

Don't  believe anyone is going to be able to get cromolyn sodium on their own, would need a doc.

Did not see much if anything from ALA, but NAC and butyrate seem to help. But I take no other meds, so I don't really know for sure.

I was able to stop bleeding just with oral NAC and butyrate, but then go what I believe to be a norovirus gut infection and

have not been able to get back on track.

Somewhere in the thread, RIT paper or patent it indicates rectal antioxidant system is not that strong.

Many many factors involved with UC.

Dysbiosis IMO is caused by excessive ROS, except in the case of antibiotic use.

OM

Old Mike said...
All you have to look at is his clinical trial results.Yes a very small trial, no question.
Don't believe anyone is going to be able to get cromolyn sodium on their own, would need a doc.
Did not see much if anything from ALA, but NAC and butyrate seem to help. But I take no other meds, so I don't really know for sure.
I was able to stop bleeding just with oral NAC and butyrate, but then go what I believe to be a norovirus gut infection and
have not been able to get back on track.
Somewhere in the thread, RIT paper or patent it indicates rectal antioxidant system is not that strong.
Many many factors involved with UC.
Dysbiosis IMO is caused by excessive ROS, except in the case of antibiotic use.
OM

Mike, you were taking ALA to treat your UC? Pravda wasn't entirely clear in his patent, but I got the impression that he suggested ALA as a maintenance medication to prevent a relapse into the induction phase. Sort of like taking oral mesalamine. "This oral therapy can be continued, along with lifestyle changes, as maintenance therapy to prevent re-initiation and relapse."

Marauder93 said...

Homer said...
If I'm understanding the patent correctly, then I think it addresses your points:

2. Initiation in the rectum
- Most amusing part from the patent: "The greatest risk factor for ulcerative colitis is the presence of a rectum."

.

This is still a MASSIVE hole though. If it was indeed caused by ROS etc, then we would have at least a few cases starting somewhere other than the rectum. Just like if UC were caused by an infection, we wouldnt see such a clear cut distinction in the location of initiation.

I can't tell if you're agreeing with the patent that UC tends to start in the rectum, or if you're disagreeing with that point

It starts at rectum probably because of microorganism population of rectum.

Tidbits from the patent's Rectum section:

"The greatest risk factor for ulcerative colitis is the presence of a rectum. Within this area of the colon a junction of physiological parameters converge to increase the potential for H2O2 generation and oxidative tissue damage (induction)...

The bacterial concentration within the colon increases distally from 10^3 cfu/gram of fecal material in the cecum to 10^13 cfu/gram in the rectum. The greatly increased concentration of, predominantly, mucosal adherent anaerobic bacteria significantly increases the likelihood of antigenic exposure in the event of a barrier breakdown. Any condition which slows colonic fecal transport allows bacteria more time to multiply...

Fecal material also generates a large amount of oxygen radicals... The increased concentration of these radicals found in the rectum, a fecal reservoir, can also contribute to colonic barrier dissolution and epithelial oxidative damage...

Rectal epithelial cells also possess an electron transport chain which may become a source of excess H2O2 if subjected to hypoxia and sudden re-oxygenation (Li and Jackson, 2002). During the time the rectum is housing feces and until they are expelled the rectal wall is subjected to lateral pressure which can compress delicate sub-mucosal blood vessels...

Constipation and straining during defecation, by increasing colonic intraluminal pressure, will enhance the effect of hypoxia/reoxygenation upon the xanthine oxidase enzyme system, increasing its activity and output of H2O2 which increases the risk of entering the induction phase of ulcerative colitis."

Why the heck isn't anyone funding a trial on this???

aguywithuc said...

Old Mike said...
Pravda has just about everything nailed down.
Until I find something better, IMO this is what is going on.
You really have to read through the whole re-visit thread, I have many links that support excess ROS and what
is going on, the trick in the end though is healing.

Old Mike

Seems to be correct. I feel I am aging faster than those around me without UC. ROS is awful.

/en.wikipedia.org/wiki/Reactive_oxygen_species#Cause_of_aging

No easy answers to ROS

www.hindawi.com/journals/omcl/2013/956792/

I wouldn't think an ROS problem limited to the colon would result in your entire body aging faster, no?

Well then yes, I would think someone who eats fruits and vegetables is going to be healthier than someone who doesn't :)