Options after Remicaid

I've been on Remicaid for about five months. It worked great and brought me out of a 7 month flare when steroids and Imuran could not. Unfortunately I started having some pain, and blood about a week before my last infusion (December 21st). It's now four days after my infusion and I'm afraid I have seen zero improvement. Usually the remicaid worked within a day or two at most. Could it be possible the remicaid is not working anymore? If that's the case what are my options after remicaid? So far I've tried mesalamines, prednisone, Imuran, and Remicaid.

I think increasing the dose or frequency would probably be an option too. You should get the antibody level checked to see if you're building antibodies. Otherwise, you could try another TNF blocker, like humira or Simponi. Since you had response to a TNF blocker, there is a good chance that another one would work. If that didn't work, entyvio would be an option. Of course, while you're trying to get on something for maintenance, you might need to take a steroid, pred or uceris, to get things under control. Are you using rectal meds? Have you tried any diets? Some people do well on SCD or some personalized form of it. Probiotics?

Remicade can be dosed up to a maximum of 10mgs per kilogram, every 4 weeks. If you initially had a response to remi, then I'd see about increasing the dose and/or frequency to regain response, again. Within 24 hours of your next scheduled infusion have a blood test done that'll measure for remicade antibody and remi concentration (e.g., anser ifx test by Prometheus labs, or infliximab concentration by labcorp).

Alternative biologics are humira, simponi, or entvyio.