I've had pretty good success with Lialda. Originally I was on 2x in the morning but during a flare I was upped to 4x in the morning. I asked my GI doctor about
splitting it 2x morning and 2x at night but she told me that it makes no difference. She should be wrong
. I've had no side effects from Lialda but it has not been a silver bullet. When I'm in a flare it makes it less of a flare. Once I'm in remission it does a good job of keeping me there as long as I don't go overboard with triggers (bad food choices, stress, etc..).