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Posted 2/14/2016 4:33 PM (GMT 0)
I'm sorry I am new to forums like this and despite trying to search I couldn't figure out where this question should go.

I was diagnosed with UC in late 2014 and have been on Lialda 2.4gms a day ever since.

I am 48 years old and in very good health, always very active.

But recently (the past several months) I have been noticing increasing joint pain in my knees and wrists mostly.

I can't understand why this is and was wondering if others have experienced similar issues with Lialda, it is the only thing I can think of that is causing this.

Thanks, and sorry if I am posting in the wrong place.
Posted 2/15/2016 1:33 AM (GMT 0)
I've had no side effects with Lialda and I have been on it for years.
Posted 2/15/2016 11:54 AM (GMT 0)
Joint pains are a common compliant with uc patients. Lialda isn't known to cause these kind of pains. I used lialda for several years without a side effect.

Uc is inflammation of the large intestine caused by the immune system. Joint pain is inflammation of the joints, caused by the immune system and it is known as arthritis.

You could ask about switching from lialda to Sulfasalazine (a similar medication) that treats uc and is known to reduce joint pain (also used with RA).
Posted 2/15/2016 12:45 PM (GMT 0)
John

Thanks for the info. I will research and ask my doc.
Posted 2/15/2016 2:06 PM (GMT 0)
I had muscle aches and tendon pain on Lialda. No joint pain. I switched to Asacol and am starting to have the same problem- I think it is the mesalamine. When I would skip a day to see if it was the medication I would feel better. Back on the pain would return.
Posted 2/16/2016 12:28 AM (GMT 0)
I think I get random headaches from lialda. I believe it is a known side effect.
Posted 2/17/2016 3:50 AM (GMT 0)
My joint pain began long before I had symptoms of active UC. The pain was in symmetrical joints (knees and hips) as well as sacral. I understand that joint pain is very common with UC and often is felt before one is symptomatic. Upon going on prednisone however, they disappeared - like magic! Now I'm almost off the pred, and... hello joint pain. Your pain could be associated with Lialda - don't rule it out. It can have significant side effects. I'm on it too, and am having some pretty bad back pain, but it's hard to tell if it's related to the pred. taper, the UC, or Lialda. I'm interested in looking into sulfasalazine suggested by ipoop.
Posted 2/17/2016 4:43 PM (GMT 0)
I had a similar experience after starting Lialda but to this day cannot tell if the Lialda caused the issues, triggered it or it was a complete coincidence. I started Lialda in November, 2013, by January 2014 I started having joint pains in my fingers, wrists and ankles. They would come and go with no apparent cause for the pain. I just assumed that it was arthritis (43 at that time). I originally was on 2 Lialda per day, I increased to 3 in June/July and the pains became significantly worse and each episode came closer to the next and lasted longer. Eventually it became hard to function (could not turn a door handle, difficult to walk, could not pour a cup of coffee) and after lots of tests, x-rays, etc. I was diagnosed with drug induced lupus suspected to be caused by the Lialda. When I stopped the Lialda the pains subsided for about 7 months but then returned at which time (after even more tests) I was diagnosed with systemic lupus. My original GI had never heard of this and the new GI I see doubts it was the Lialda but nobody, including me or my rheumatologist knows for sure. My rheumy stated it is one of three possibilities, Lialda (mesalamine) caused the Lupus or it triggered the Lupus or it was a complete coincidence. In my mind, I think it triggered the lupus or caused it. If you have any specific questions, feel free to ask, happy to share what I've learned along the way.
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