Looks like this might somewhat contradict theory,there might be some hope after all, but perhaps
not long term. They did clinical trials,Oral administration of Alequel, a mixture of autologous colon-extracted proteins for the treatment of Crohn’s disease.
Wonder why they used colon extracted on crohns as opposed to UC.
http://www.nature.com/cti/journal/v5/n1/full/cti201547a.html
clinical trial, and they did use some proteins from the ileum is some people.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002565/
ah, the plot thickens, it seems that only proteins that are not fully digested induce tolerance,
the trick is along with the proteins use sodium bicarbonate to interfere with digestion, nice trick.
This for food allergy, but who knows might apply to systemic immune response somehow,once tolerance
is broken.
Complete degradation of peanut via the combined effects of stomach and intestinal enzymes has been demonstrated by sequential digests of peanut extract (gastric digests followed by intestinal digests) (Vieths et al., 1999). Oral tolerance to peanut and Brazil nut was enhanced by adding sodium bicarbonate to the dosing solution. Sodium bicarbonate treatment increased the pH of the solution from 7.5 to 8.8, likely inhibiting stomach pepsin activity during oral exposure (Kopper et al., 2004). Limiting digestion of peanut and Brazil nut may have preserved the stomach labile proteins, some of which were resistant to intestinal enzymes, and therefore supplied intact antigens to the intestine for immune processing and subsequent tolerance induction
http://toxsci.oxfordjournals.org/content/106/2/435.full
Now this brings up the thought, especially for perhaps IBD, we ingest lots of antigens,is our digestion too good.
Should we, take some sodium bicarbonate with each meal.
The idea is partial breakdown of the proteins, not complete, or none.
Another study has shown that inhibition of digestion blocks oral tolerance to ovalbumin. Cimetidine treatment of mice prior to ingestion of ovalbumin leads to decreased tolerance, while oral administration of pepsin-treated ovalbumin to cimetidine-treated mice results in immune unresponsiveness (Jain and Michael, 1995). Taken together, these findings suggest that an intermediate level of digestion is optimal for tolerance induction
then again might immunize-not good
http://iai.asm.org/content/67/11/5917.full
oldie but goodie
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1773925/
Old Mike
Post Edited (Old Mike) : 4/9/2016 3:10:50 AM (GMT-6)