Several people have said that Wellbutrin has actually helped with UC because it is a mild TNF blocker.
www.docguide.com/bupropion-may-aid-patients-inflammatory-bowel-disease-presented-sfn Bupropion (Wellbrtrin) lowered levels of tumor necrosis factor (TNF) in 8 patients who were taking bupropion for depression, with 7 entering the normal range for the inflammatory agent. Levels of TNF ranged from 20 to 1250 pg/mL before bupropion, and dropped to 14 to 2 pg/ml afterwards. One patient's levels remained elevated, at 94 pg/mL.