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Anti-inflammatory efficacy of turmeric oil and curcumin in colitis.

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Ulcerative Colitis
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Posted 4/14/2017 2:58 AM (GMT 0)
"Considering that curcumin is a readily available, safe and a cost-effective botanical, there is a growing interest in exploring its clinical efficacy individually or as an adjunctive treatment for managing and/or treating UC and subsequently improving the overall quality of life for patients with this inflammatory disease.

Although curcumin is a well-established anti-inflammatory agent, the exact mechanism(s) by which it attenuates inflammatory burden in diseases such as UC remains unclear. Herein, we demonstrated that curcumin exhibited significant anti-inflammatory effects in a mouse model of dextran sodium sulfate (DSS)-induced colitis.

In particular, a unique formulation of curcumin containing essential turmeric oils (ETO-curcumin) displayed greater anti-inflammatory efficacy compared to the standard curcumin, as evidenced by the reduced disease activity index (DAI) and changes in gene expression alterations of the inflammation-related genes, highlighting that ETO enhances the anti-inflammatory efficacy of curcumin.' - https://www.nature.com/articles/s41598-017-00812-6
Posted 4/14/2017 3:21 AM (GMT 0)
I took 95% concentrated curcumin/turmeric capsules for a year instead of Balsalazide and my gut loved it (so did my wallet). However I think my dose was too high (2-4 g daily) because I ended up with 2 separate skin infections that I believe were the result of being in such a non-inflammatory state that normal cuts did not heal. A certain amount of inflammation is necessary to signal there body to heal those areas. I never had skin infections before taking curcumin and since stopping it (back to Balsalazide) not a single infection although I always get cuts from gardening, it's a contact sport for me.

I hope dosages are studied because curcumin could be very valuable for people who are intolerant of mesalamines. It worked as well as Balsalazide does for my UC, possibly a little better. It is very powerful, too much for my body but at a lower level might have been perfect.
Posted 4/14/2017 3:02 PM (GMT 0)
The ETO extract is interesting. Depending on details it might be able to enter the market as a supplement, or it may have to go through drug approval. (Hey, willow-bark derivatives has to go through drug approval).

Also if the mechanism is systemic, it has a better chance of being a medical food/supplement. If it is topical, and is combined with a delivery system such as enteric coating or such, then it would definitely need drug approval.

But derivatives of this plant may supplement 1st line derivatives of willow bark (aka mesalamine) in the next 6 to 10 years.
Posted 4/14/2017 3:59 PM (GMT 0)
There is a great Turmeric Users group on Facebook.....I joined awhile back. I may have to revisit this idea!
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