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P-anca and ASCA negative?

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Ulcerative Colitis
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Posted 7/11/2017 4:15 AM (GMT 0)
Does this lead to any belief or hope that maybe I don't have UC?

Review of my 1st post:

June 4th, my username I was a completely healthy 37 year old male with no prior medical problems, medications, etc. The following day I got really sick with flu like symptoms that went away on their own in 4 days. But diarrhea (or more like frequent bowel movements, not liquid more like soft yogurt) lasted for much longer. After 4 docs, 1 ER, 1 colonoscopy, stool tests etc the major.findings were :

Inflammation in the cecum intestine
No findings in the stool other than positive lactoferein
The antibiotics ER gave me flagyl and cipro cured the frequent bm's and pain.
Colonoscopy found same inflammation as CT scan
Finger test had blood traces
My frequent bm's never had blood, and no abdominal pain.
Rectal pain came about 2 weeks which now I'm nearly 100% sure is from my fistula/abscess
My bm's have been regular for more or less 37 years, no abdominal pain ever, no blood in stools.
I did lose 10 lbs during my illness but it's coming back now before I started the budesonide.
Eat extremely healthy but do eat some dairy, and Def drink caffeine which has never bothered my stomach.


Thanks for taking the time time read.
Posted 7/11/2017 7:08 AM (GMT 0)
what is P-anca and ASCA?
Posted 7/11/2017 8:22 AM (GMT 0)
p-anca and asca are specific antibodies that are associated with IBD.

p-anca stands for perinuclear anti-neutrophil cytoplasmic antibody. If I remember right, it's associated more with having UC.

asca is anti-saccharomyces cerevisiae antibody. There are two types of this antibody, IgA and IgG. Having these is more associated with having Crohn's disease.
Posted 7/11/2017 8:28 AM (GMT 0)
June4th, are you saying you had these tested and both were negative?

Also, are you saying you have a fistula and abscess? Where exactly, and how has it been treated? And what doctor diagnosed it and treats it? And have MRIs of it been done?

Fistulae are more associated with Crohn's disease, and much less so with UC.
Posted 7/11/2017 3:38 PM (GMT 0)
Do you have a copy of your biopsies pathology results?

q
Posted 7/11/2017 3:56 PM (GMT 0)
The fistula/abscess is on my perinium. It has to be surgically removed or drained Saturday by a Colorectal surgeon. They sonogram and ct scanned it.

I am waiting for copies of my biopsy report.
Posted 7/11/2017 4:34 PM (GMT 0)
Let us know the results of the c-scope biopsies. Hope your fistula surgery recovery goes smoothly. Keep us updated.

q
Posted 7/11/2017 5:13 PM (GMT 0)
We're not doctors, haven't seen your test results, and can only guess like you. It's possible you have UC and it's also possible you do not have it but I will differ to your gasteroenteroligist. I agree with getting a copy of your colonoscopy report, biopsy report, and the P-anca and ASCA test results you are talking about. The P-anca and ASCA test is pretty darn new, and therefore isn't as fully trusted as the results of a colonoscopy with biopsies.

A typical, storybook case of UC is a negative stool test for pathogenic causes, has a colonoscopy report that states inflammation began in the rectum and was distal (continuous) up the large intestine showing permanent architectural changes, and the biopsies confirm permanent architectural changes are present (things like a disrupted rather than orderly blood vessel pattern, crypt abscesses, and unusual cell features). Prior to my diagnosis I had a lot of blood in the toilet water with each and every BM, and blood is often what causes us to seek out a diagnosis. If the above does not sound like you, then it'd certainly cast doubt on a UC diagnosis.
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