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Posted 7/13/2017 7:18 PM (GMT 0)
Hi All,

After my colonoscopy last week I have been prescribed salofalk granules 3g a day. Think it might also be called Apriso... I am experiencing some worsening in diarrhea. I've only been taking it t a few days but it definitely seems to have caused more diarrhea, does anyone know it to this might settle in time?

Can anyone share their experience in using salofalk granules?

Also the Dr has advised that I can also use prednisolone foam. I have some pred foam here but I had started using it just over a month ago only a few times, do you think it would be still ok to use?

Thanks

LoopyLou
Posted 7/13/2017 7:37 PM (GMT 0)
Yes....try it.

If you could get mesalamine enemas, it could be a better option at this time,

While it is possible that you could be sensitive to the oral granules, please keep in perspective that a colon crazy inflamed and in a flare doesnt garner quick results with mesalamine. Plus, you aren't on rectals.

How many times a day are you having bms?

Diarrhea or really loose stool?

What are the results of your c- scope? How high is the inflammation?
Are you bleeding?

Hang tough....you still have lots of med options to exhaust. But patience for a few weeks yet.
q
Posted 7/13/2017 7:39 PM (GMT 0)
The foam will not expire in a month.

Some people report initial worsening of D with mesalamines. IF you are allergic to it, there would be a lot of D and gas.

It is one of the safest meds, so if the D is not too bad I would try to give it a 3-4 week trial. I see you had a bad reaction to mesalamine enemas - but also to cort enemas - so it is not clear that you have issues with mesalamine. For example it may have been sulfate in both enemas.

The issue becomes what therapy will you switch to if you abandon Salofalk?

good luck
Posted 7/13/2017 7:49 PM (GMT 0)
Fine to use the month old steroid foam.

Some do report a mesalamine intolerance and it is described as a dramatic worsening of UC symptoms, like before having 3 solid bms a day without urgency, and then going to 6-8 very urgent and loose bms a day once on mesalamine. If that sounds like you, then it is possible. If not then it isn't.

I'd try not to judge based on a single day as well. If it happens consistently then it could be a problem.
Posted 7/13/2017 8:14 PM (GMT 0)
Thanks Quincy, I should have said I've been on pred liquid enemas since my colonoscopy but they don't seem to be working as effectively (I've used them on and off for several months this year) so my Dr suggested trying predfoam because it can be used twice a day as opposed to once a day. I'm going to give the foam a go.

It's diarrhea unfortunately, just liquid mixed with mucus (Sorry for too much info!) I was going 3 times loose stool with blood clots now going 5 or 6 times with tiny amount of blood. Really struggling because the duarrhea is terrible even though I haven't been eating eating for over a week, only living on broth and jelly.

Inflammation up to splenic flexure but GI is still not sure if UC or Crohns. My GI thought the ulcers looked like apthous ulcers. Waiting for biopsy results.

Thanks DBwithUC yes I think I'm going to have to stick with the salofalk for a few weeks and hope the diarrhea settles. Hopefully it is just the enemas my colon doesn't react well too.

Thanks iPoop, will try the foam. I don't think it's been as dramatic a reaction as you've described, will see how I go over the next week. Maybe it's just an initial reaction until my colon adjusts...

The mesalazine enema I had a reaction too was pentasa, so I'm wondering whether the salofalk one might be worth a try?
Posted 7/14/2017 12:56 AM (GMT 0)
You don't have biopsies pathology back yet?
Did you have stool samples checked for invaders?


Have you been checked for h. Pylori?

Last question...are you taking the geanules all at once or splitting the dosage?
q
Posted 7/14/2017 9:52 AM (GMT 0)
If they come back as apthous ulcers then it is crohn's disease, wait and see...

I'd stick out the salofalk granules for a week, skip them for 48 hours and see if things drammatically improve without them (as that'd poimt to an intolerance).

Post Edited (iPoop) : 7/14/2017 3:55:05 AM (GMT-6)

Posted 7/14/2017 12:27 PM (GMT 0)
Thanks Quincy, my first biopsy results showed inflammatory bowel disease type unspecified but haven't received the results of the last one yet.

Stool samples were clear of invaders and h pylori was clear also.

Yes I've been taking the granules split by 1 g per dose.

Diarrhea was much much worse this morning to the point I didn't make it to the toilet. Absolutely mortifying.... Just glad I was in my own home.

Thanks iPoop. Good idea to try stop taking it for 48 hours to see what happens.
Posted 7/14/2017 6:34 PM (GMT 0)
Just come back from seeing my Dr and she has changed me from salofalk to basalazide to see if that might work better for me and lessen the diarrhea.

She also said my calprotectin came back as 456 which she said was above the normal range. I've never had this test before, is that result quite high?

She's also told me to take a liquid supplement drink called ensure plus as I am underweight at 43 kg now, used to be about 55 kg beginning of this year....
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