So many people here have used the enemas during pregnancy. I would consult with your OB or a high risk OB if you have questions, but they are topical and I can't see it causing any issues. Some people are on 6mp/imuran, remicade, prednisone, all while pregnant... Mesalamine enemas are really a very safe drug. The worst would be passing UC genetics, I'd be much more worried about
that then using enemas personally.
Here's a post i found in a quick search:
/www.healingwell.com/community/default.aspx?f=38&m=2989535